Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SMC3 |
| Full Name | Structural Maintenance of Chromosomes 3 |
| Aliases | Page for SMC3 |
| Function | The SMC3 ATPase head domain hydrolyzes ATP to drive conformational changes that regulate cohesin loading, translocation, and release from chromatin. |
| Ensembl ID | ENSG00000103052 |
| GeneCards | SMC3 |
| Human Protein Atlas | SMC3 |
| Loop extrusion | Generating topologically associating domains (TADs) that organize the genome into functional compartments |
| Enhancer-promoter contacts | Facilitating long-range regulatory interactions |
| Gene expression programs | Regulating activity-dependent neuronal gene expression[@rao2014] |
| Intellectual disability | Disrupted cohesin-mediated gene regulation |
| Autism spectrum disorder | Altered synaptic gene expression programs |
| Seizures | Aberrant neuronal network development[@gomperts2009] |
| Associated Diseases | Als |
| Interactions | HDAC8 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SMC3["SMC3"]
Als{"Als"}
SMC3 -->|"associated_with"| Als
Cancer{"Cancer"}
SMC3 -->|"therapeutic_target"| Cancer
BRD4["BRD4"]
SMC3 -->|"associated_with"| BRD4
RAD21["RAD21"]
SMC3 -->|"associated_with"| RAD21
HDAC8["HDAC8"]
SMC3 -->|"inhibits"| HDAC8
Raf("Raf")
SMC3 -->|"therapeutic_target"| Raf
App("App")
SMC3 -->|"therapeutic_target"| App
SMC1A["SMC1A"]
SMC1A -->|"associated_with"| SMC3
ANKRD11["ANKRD11"]
ANKRD11 -->|"associated_with"| SMC3
NIPBL["NIPBL"]
NIPBL -->|"associated_with"| SMC3
HDAC8 -->|"associated_with"| SMC3
neurodegeneration["neurodegeneration"]
SMC3 -->|"implicated_in"| neurodegenerationHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||