Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RELNPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RELNPROTEIN |
| Full Name | Reelin |
| Chromosome | 7q22.1 |
| Protein Family | Reelin family |
| Target Class | Signaling Protein |
| Mechanism of Action | Drugs targeting RELN would primarily work by enhancing reelin expression or signaling through its receptors (VLDLR and ApoER2) to promote neuronal migration, synaptic plasticity, and cognitive function. Alternatively, pathway modulators could enhance downstream signaling cascades (Dab1-mediated pathways) to compensate for reelin deficiency or dysfunction. |
| Primary Expression | Cortex, hippocampus, cerebellum |
| Druggability | Low (0.33) |
| Clinical Stage | Approved |
| Molecular Weight | ~388 kDa (full-length) |
| Amino Acids | 460 aa |
| UniProt ID | P78536 |
| GeneCards | RELNPROTEIN |
| Human Protein Atlas | RELNPROTEIN |
| Associated Diseases | AD, Als, Alzheimer, Alzheimer disease |
| Known Drugs/Compounds | valproic acid |
| Interactions | AD, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOE, APOE3 |
| SciDEX Target | View Target Profile (9 clinical trials) |
| SciDEX Hypotheses | Reelin-Mediated Cytoskeletal Stabilization Protoco Reelin Signaling Enhancement |
| KG Connections | 295 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RELNPROTEIN["RELNPROTEIN"]
neurodegeneration["neurodegeneration"]
RELNPROTEIN -->|"implicated_in"| neurodegeneration
style RELNPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RELNPROTEIN in their description or question text
No additional research found