Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about valproic acid: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| hyperammonemia | causes | phenotype | 0.90 |
| autism | treats | disease | 0.70 |
| neuroinflammation | treats | disease | 0.70 |
| ferroptosis | modulates | pathway | 0.70 |
| CHRNA7 | regulates | gene | 0.60 |
| CHRNA7 | modulates | gene | 0.60 |
| CHRNA7 | causes | gene | 0.60 |
| CHRNA7 | expressed_in | gene | 0.60 |
| HDAC3 | activates | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| HDAC3 | inhibits | gene | 0.60 |
| STAT1 | inhibits | gene | 0.60 |
| STAT1 | regulates | gene | 0.60 |
| STAT1 | treats | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| TNF | treats | gene | 0.60 |
| RELN | activates | gene | 0.60 |
| RELN | inhibits | gene | 0.60 |
| ACSL4 | activates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| GPX4 | activates | gene | 0.60 |
| TFR1 | activates | gene | 0.60 |
| ACSL4 | regulates | gene | 0.60 |
| SLC7A11 | regulates | gene | 0.60 |
| GPX4 | regulates | gene | 0.60 |
| TFR1 | regulates | gene | 0.60 |
| ACSL4 | treats | gene | 0.60 |
| GPX4 | treats | gene | 0.60 |
| TFR1 | treats | gene | 0.60 |
| GPX4 | inhibits | gene | 0.60 |
| ACSL4 | inhibits | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| epigenetic regulation | modulates | pathway | 0.60 |
| DNA | modulates | gene | 0.60 |
| NF-kB signaling | modulates | pathway | 0.60 |
| HDAC | inhibits | gene | 0.60 |
| HDAC | regulates | gene | 0.60 |
| GSH | activates | gene | 0.60 |
| GSH | regulates | gene | 0.60 |
| GSH | treats | gene | 0.60 |
| unfolded protein response | modulates | pathway | 0.60 |
| GSH | inhibits | gene | 0.60 |
| necroptosis | modulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURON | inhibits | cell_type | 0.65 |
| HDAC3 | associated_with | gene | 0.45 |
| STAT1 | associated_with | gene | 0.45 |
| SPINAL CORD INJURY | associated_with | disease | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| SPINAL CORD | associated_with | brain_region | 0.45 |
| MICROGLIA | associated_with | cell_type | 0.45 |
| NEURODEGENERATION | associated_with | disease | 0.45 |
| PI3K/AKT PATHWAY | associated_with | pathway | 0.45 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||