gene

RETREG3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RETREG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	RETREG3
Full Name	Reticulophagy Regulator 3
Chromosome	5q31.1
Function	is a critical endoplasmic reticulum (ER)-resident protein that functions as an autophagy receptor mediating reticulophagy—the selective degradation of ER components through the autophagy-lysosome p...
Subcellular Localization	. This region shows less conservation compared to RETREG1, suggesting possible functional divergence between the two par
Molecular Weight	48 kDa
Amino Acids	449 aa
Exons	7
UniProt ID	Q8N6I6
NCBI Gene ID	642473
Ensembl ID	ENSG00000175318
OMIM	-
GeneCards	RETREG3
Human Protein Atlas	RETREG3
Protein Class	ER-phagy receptor, autophagy adaptor
Associated Diseases	Parkinson's Disease, Alzheimer's Disease
Interactions	LC3, AUTOPHAGY
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RETREG3 — AlphaFold Q8N6I6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RETREG3 (Reticulophagy Regulator 3)

gene · 2881 words

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Genes

index · 271 words

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Pathway Diagram

graph TD
    RETREG3["<b>RETREG3</b>"]
    AUTOPHAGY["AUTOPHAGY"]
    RETREG3 -->|"interacts with"| AUTOPHAGY
    BMPR1A["BMPR1A"]
    RETREG3 -->|"regulates"| BMPR1A
    ATG5["ATG5"]
    RETREG3 -->|"regulates"| ATG5
    LC3["LC3"]
    RETREG3 -->|"interacts with"| LC3
    Autophagy(["Autophagy"])
    RETREG3 -->|"interacts with"| Autophagy
    neurodegeneration["neurodegeneration"]
    RETREG3 -->|"implicated in"| neurodegeneration
    style RETREG3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
BMPR1A	regulates	gene	0.60
ATG5	regulates	gene	0.60
LC3	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found