gene

ATG5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1675Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

ATG5 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with AD, ALS, AMI. Connected to 833 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG5
Full Name	Autophagy Related 5
Chromosome	6q21
Function	ATG5 is central to autophagy: - Autophagosome formation: Essential for the expansion and closure of the autophagosome - ATG12-ATG5-ATG16L1 complex: Functions as an E3-like enzyme for LC3 lipidation -
Molecular Weight	~32 kDa
Pathways	AUTOPHAGY_PATHWAY, Autophagy, Camp Signaling, Chaperone, Chemoresistance
GeneCards	ATG5
Human Protein Atlas	ATG5
Associated Diseases	AD, ALS, AMI, ARM, Ataxia
Known Drugs/Compounds	CURCUMIN, curcumin, nicotinamide, statins, rapamycin, RAPAMYCIN
Interactions	EIF4EBP1, LC3, MTOR, ABCG1, SQSTM1, ABCA1
KG Connections	1675 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATG5(["ATG5"])
    Autophagy["Autophagy"]
    Inflammation["Inflammation"]
    P62(["P62"])
    LC3(["LC3"])
    Als["Als"]
    AUTOPHAGY(["AUTOPHAGY"])
    INFLAMMATION(["INFLAMMATION"])
    AMPK(["AMPK"])

    ATG5 -->|"activates"| Autophagy
    ATG5 -.->|"inhibits"| Inflammation
    ATG5 -->|"associated with"| Autophagy
    ATG5 -->|"activates"| Inflammation
    ATG5 -.->|"inhibits"| Autophagy
    ATG5 -->|"activates"| P62
    ATG5 -->|"activates"| LC3
    ATG5 -->|"activates"| Als
    ATG5 -->|"associated with"| AUTOPHAGY
    ATG5 -->|"activates"| AUTOPHAGY
    ATG5 -->|"activates"| INFLAMMATION
    AUTOPHAGY -->|"activates"| ATG5
    ATG5 -->|"activates"| AMPK
    ATG5 -->|"associated with"| LC3
    AUTOPHAGY -.->|"inhibits"| ATG5

    style ATG5 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1164)

Target	Relation	Type	Str
P62	activates	gene	1.00
LC3	activates	gene	1.00
Autophagy	activates	pathway	1.00
Inflammation	inhibits	disease	1.00
Autophagy	associated_with	pathway	1.00
Inflammation	activates	disease	1.00
Autophagy	inhibits	pathway	1.00
Als	activates	disease	1.00
AUTOPHAGY	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
LC3	associated_with	gene	1.00
AMPK	activates	gene	1.00
ER-Mitochondria Contact Site	associated_with	mechanism	0.95
macroautophagy	involved_in	process	0.95
Cancer	activates	disease	0.95
Infection	activates	disease	0.95
autophagosome formation	involved_in	process	0.92
Autophagy	involved_in	process	0.92
autophagy	regulates	pathway	0.90
autophagy	participates_in	pathway	0.90
ferroptosis	protects_against	phenotype	0.90
autophagy	activates	pathway	0.90
Selective Autophagy	involved_in	pathway	0.90
NLRP3 Inflammasome Inhibition	mediates	mechanism	0.90
Hippocampal Neurogenesis	regulates	phenotype	0.90
AUTOPHAGY	involved_in	entity	0.90
oxidative stress response	participates_in	pathway	0.90
ATG7	associated_with	gene	0.90
MTOR	activates	gene	0.90
ATG7	activates	gene	0.90
ULK1	activates	gene	0.90
BECLIN1	activates	gene	0.90
Apoptosis	activates	pathway	0.90
Mtor	activates	pathway	0.90
Immune Response	activates	pathway	0.90
INFLAMMATION	inhibits	gene	0.90
NLRP3	degrades	protein	0.88
Nlrp3 Inflammasome Inhibition	involved_in	mechanism	0.88
Neuroinflammation	modulates	process	0.88
Macroautophagy	mediates	process	0.85
NLRP3 Degradation	mediates	process	0.85
NLRP3 Inflammasome Activation	mediates	process	0.85
NLRP3	mediates	protein	0.85
NLRP3 Inflammasome Inhibition	involved_in	mechanism	0.85
P2Ry12 Inhibitor-Induced Cholesterol Efflux	mediates	phenotype	0.85
Tumor	activates	disease	0.85
Neurodegeneration	activates	disease	0.85
Ferroptosis	contributes_to	process	0.85
Autophagy	mediates	process	0.85

Incoming (511)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
AUTOPHAGY	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
paeoniflorin	contributes_to	drug	0.90
ESRRA	upregulates	gene	0.90
FTO	regulates	protein	0.90
YTHDF2	inhibits	protein	0.90
USP22	associated_with	protein	0.90
Paeoniflorin	upregulates	compound	0.87
Ubiquitination	regulates	process	0.85
TRIM45	interacts_with	protein	0.85
USP22	downregulates	gene	0.85
TFEB	upregulates	entity	0.80
ATG	component_of	gene	0.80
TRIM45	activates	gene	0.80
BECN1	activates	gene	0.80
TNF	inhibits	gene	0.80
TNF	activates	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
PAK1	phosphorylates	protein	0.70
BECN1	inhibits	gene	0.70
PINK1	expressed_in	gene	0.70
BECN1	associated_with	gene	0.70
ULK1	causes	gene	0.70
ATG	interacts_with	gene	0.70
MITOPHAGY	activates	gene	0.70
ATG	associated_with	gene	0.70
INFLAMMATION	inhibits	gene	0.70
AUTOPHAGY	expressed_in	gene	0.70
APOPTOSIS	inhibits	gene	0.70
ROS	activates	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
GFP	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
USP22	interacts_with	gene	0.70
ATG12	associated_with	gene	0.65
APP	associated_with	gene	0.65
AKT	activates	gene	0.65
AKT	phosphorylates	gene	0.65
NLRP3	mediated_by	gene	0.65
NLRP3	promotes	gene	0.65
ULK1	inhibits	gene	0.65
AMPK	associated_with	gene	0.65
ASTROCYTE	associated_with	gene	0.65
PYROPTOSIS	mediated_by	process	0.65
NLRP3 INFLAMMASOME	degrades	pathway	0.65
AUTOPHAGY	targets	phenotype	0.65
RAPAMYCIN	treats	drug	0.65
OXIDATIVE STRESS	protects_against	phenotype	0.65
GLUTAMATE	inhibits	phenotype	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG5

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG5 — Autophagy Related 5

cbs-psp-daily-action-plan

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Pathway Diagram

Outgoing (1164)

Incoming (511)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Epigenetic reprogramming in aging neurons

Sleep disruption as cause and consequence of neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Related Papers (0)

ATG5

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG5 — Autophagy Related 5

cbs-psp-daily-action-plan

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

rapamycin-tauopathy

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

FOXO4 — Forkhead Box O4

Circadian Disruption in Neurodegeneration

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

autophagy-lysosome-dysfunction

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

Regulated Necrosis Hypothesis in Parkinson's Disease

Sirtuin Signaling in Parkinson's Disease

Adult Neurogenesis in Neurodegeneration

MAP1LC3A Gene

Lysosomal Dysfunction in Progressive Supranuclear Palsy

Tau Proteostasis and Clearance Across 4R-Tauopathies

RETREG3 (Reticulophagy Regulator 3)

Pathway Diagram

Outgoing (1164)

Incoming (511)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Epigenetic reprogramming in aging neurons

Sleep disruption as cause and consequence of neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Related Papers (0)