gene

ATG5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1775Connections

0Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

7Debates

Summary

ATG5 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with AD, ALS, AMI. Connected to 833 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG5
Full Name	Autophagy Related 5
Chromosome	6q21
Function	ATG5 is central to autophagy: - Autophagosome formation: Essential for the expansion and closure of the autophagosome - ATG12-ATG5-ATG16L1 complex: Functions as an E3-like enzyme for LC3 lipidation -
Molecular Weight	~32 kDa
Pathways	AUTOPHAGY_PATHWAY, Autophagy, Camp Signaling, Chaperone, Chemoresistance
GeneCards	ATG5
Human Protein Atlas	ATG5
Associated Diseases	AD, Als, AMI, ARM, Ataxia
Known Drugs/Compounds	curcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN, statins
Interactions	4E-BP1, ABCA1, ABCG1, ACETYL-COA, ACHE, ACSL4
KG Connections	1774 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATG5(["ATG5"])
    Autophagy["Autophagy"]
    Inflammation["Inflammation"]
    P62(["P62"])
    LC3(["LC3"])
    Als["Als"]
    AUTOPHAGY(["AUTOPHAGY"])
    INFLAMMATION(["INFLAMMATION"])
    AMPK(["AMPK"])

    ATG5 -->|"activates"| Autophagy
    ATG5 -.->|"inhibits"| Inflammation
    ATG5 -->|"associated with"| Autophagy
    ATG5 -->|"activates"| Inflammation
    ATG5 -.->|"inhibits"| Autophagy
    ATG5 -->|"activates"| P62
    ATG5 -->|"activates"| LC3
    ATG5 -->|"activates"| Als
    ATG5 -->|"associated with"| AUTOPHAGY
    ATG5 -->|"activates"| AUTOPHAGY
    ATG5 -->|"activates"| INFLAMMATION
    AUTOPHAGY -->|"activates"| ATG5
    ATG5 -->|"activates"| AMPK
    ATG5 -->|"associated with"| LC3
    AUTOPHAGY -.->|"inhibits"| ATG5

    style ATG5 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1264)

Target	Relation	Type	Str
ATG5	encodes	protein	0.00
autophagy	activates	pathway	1.00
P62	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Inflammation	activates	disease	1.00
LC3	activates	gene	1.00
Autophagy	activates	pathway	1.00
Inflammation	inhibits	disease	1.00
INFLAMMATION	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
Als	activates	disease	1.00
Autophagy	associated_with	pathway	1.00
Autophagy	inhibits	pathway	1.00
AMPK	activates	gene	1.00
LC3	associated_with	gene	1.00
ER-Mitochondria Contact Site	associated_with	mechanism	0.95
Cancer	activates	disease	0.95
Infection	activates	disease	0.95
macroautophagy	involved_in	process	0.95
autophagosome formation	involved_in	process	0.92
autophagy	regulates	pathway	0.90
Hippocampal Neurogenesis	regulates	phenotype	0.90
ferroptosis	protects_against	phenotype	0.90
autophagy	participates_in	pathway	0.90
Selective Autophagy	involved_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
NLRP3 Inflammasome Inhibition	mediates	mechanism	0.90
Immune Response	activates	pathway	0.90
Apoptosis	activates	pathway	0.90
BECLIN1	activates	gene	0.90
ULK1	activates	gene	0.90
MTOR	activates	gene	0.90
ATG7	activates	gene	0.90
Mtor	activates	pathway	0.90
INFLAMMATION	inhibits	gene	0.90
ATG7	associated_with	gene	0.90
Neuroinflammation	modulates	process	0.88
Nlrp3 Inflammasome Inhibition	involved_in	mechanism	0.88
NLRP3	degrades	protein	0.88
NLRP3 Inflammasome Inhibition	involved_in	mechanism	0.85
Ferroptosis	contributes_to	process	0.85
NLRP3 Inflammasome Activation	mediates	process	0.85
Macroautophagy	mediates	process	0.85
NLRP3 Degradation	mediates	process	0.85
Autophagy	mediates	process	0.85
P2Ry12 Inhibitor-Induced Cholesterol Efflux	mediates	phenotype	0.85
Tumor	activates	disease	0.85
NLRP3	mediates	protein	0.85
Neurodegeneration	activates	disease	0.85
neurons	activates	cell_type	0.80

Incoming (511)

Source	Relation	Type	Str
ATG5	encodes	gene	0.00
AUTOPHAGY	activates	gene	1.00
AUTOPHAGY	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
paeoniflorin	contributes_to	drug	0.90
TFEB	induces_transcription	transcription_factor	0.90
ESRRA	upregulates	gene	0.90
FTO	regulates	protein	0.90
YTHDF2	inhibits	protein	0.90
USP22	associated_with	protein	0.90
Paeoniflorin	upregulates	compound	0.87
TRIM45	interacts_with	protein	0.85
Ubiquitination	regulates	process	0.85
BECN1	cooperates_with	gene	0.85
USP22	downregulates	gene	0.85
TRIM45	activates	gene	0.80
ATG	component_of	gene	0.80
TFEB	upregulates	entity	0.80
BECN1	activates	gene	0.80
TNF	activates	gene	0.80
TNF	inhibits	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
AIF1	protects_against	gene	0.70
ACHE	activates	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	regulates	disease	0.70
NEURODEGENERATION	associated_with	gene	0.70
ULK1	causes	gene	0.70
BECN1	associated_with	gene	0.70
APOPTOSIS	inhibits	gene	0.70
PINK1	expressed_in	gene	0.70
AUTOPHAGY	expressed_in	gene	0.70
ROS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
USP22	interacts_with	gene	0.70
INFLAMMATION	inhibits	gene	0.70
BECN1	inhibits	gene	0.70
ATG	interacts_with	gene	0.70
GFP	activates	gene	0.70
ATG	associated_with	gene	0.70
PAK1	phosphorylates	protein	0.70
ATG12	associated_with	gene	0.65
APP	associated_with	gene	0.65
RAPAMYCIN	treats	drug	0.65
OXIDATIVE STRESS	protects_against	phenotype	0.65
AKT	phosphorylates	gene	0.65
AKT	activates	gene	0.65
GLUTAMATE	inhibits	phenotype	0.65
PYROPTOSIS	associated_with	process	0.65
AUTOPHAGY	targets	phenotype	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (7)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning ATG5 in their description or question text

No additional research found

ATG5

Understanding Entity Pages

Summary

Wiki Pages (3)

ATG5 — Autophagy Related 5

ATG5 Protein

ATG5 — ATG5 Protein

Pathway Diagram

Outgoing (1264)

Incoming (511)

Targeting Hypotheses (0)

Mentioning Analyses (5)

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

Epigenetic reprogramming in aging neurons

Sleep disruption as cause and consequence of neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Experiments (0)

Related Papers (0)

Debates (7)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

The debate identified this as a critical mechanistic gap - TFEB may increase lys

Epigenetic reprogramming in aging neurons

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

Sleep disruption as cause and consequence of neurodegeneration

Related Research