Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BMPR1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BMPR1A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, inhibits, regulates. Connected to 18 entities in the SciDEX knowledge graph.
| Gene Symbol | BMPR1A |
| Full Name | Bone Morphogenetic Protein Receptor Type 1A |
| Chromosome | 10q22.3 |
| Protein Type | Serine/Threonine Kinase |
| Function | Upon ligand binding, BMPR1A forms a heteromeric complex with type II receptors (BMPR2, ACVR2A, ACVR2B) [1]. |
| Molecular Weight | 60 kDa |
| Amino Acids | 532 aa |
| Pathways | BMP signaling |
| Ensembl ID | ENSG00000107779 |
| GeneCards | BMPR1A |
| Human Protein Atlas | BMPR1A |
| Extracellular domain | Ligand-binding region with cysteine-rich motifs |
| Transmembrane domain | Single-pass membrane anchor |
| MAPK pathways | Activation of ERK, JNK, and p38 MAPK |
| PI3K/AKT pathway | Pro-survival signaling |
| Associated Diseases | demyelination, neurodegeneration |
| Interactions | ATG5, LC3, SMAD1, BMPR2, FAM134C, FGFR3 |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BMPR1A["<b>BMPR1A</b>"]
TREM2["TREM2"]
BMPR1A -->|"upregulates"| TREM2
neurodegeneration["neurodegeneration"]
BMPR1A -->|"causes"| neurodegeneration
demyelination["demyelination"]
BMPR1A -->|"causes"| demyelination
SMAD4["SMAD4"]
BMPR1A -->|"associated with"| SMAD4
BMP_signaling(["BMP signaling"])
BMPR1A -->|"participates in"| BMP_signaling
SMAD1["SMAD1"]
BMPR1A -->|"activates"| SMAD1
FAM134C["FAM134C"]
BMPR1A -->|"inhibits"| FAM134C
GDF15["GDF15"]
BMPR1A -->|"interacts with"| GDF15
BMPR2["BMPR2"]
BMPR1A -->|"interacts with"| BMPR2
FGFR3["FGFR3"]
BMPR1A -->|"interacts with"| FGFR3
RSPO3["RSPO3"]
BMPR1A -->|"interacts with"| RSPO3
ATG5["ATG5"]
BMPR1A -->|"inhibits"| ATG5
microglia["microglia"]
microglia -->|"regulates"| BMPR1A
RETREG3["RETREG3"]
RETREG3 -->|"regulates"| BMPR1A
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"inhibits"| BMPR1A
style BMPR1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TREM2 | upregulates | gene | 0.80 |
| neurodegeneration | causes | phenotype | 0.80 |
| demyelination | causes | phenotype | 0.80 |
| SMAD4 | associated_with | gene | 0.80 |
| BMP signaling | participates_in | pathway | 0.80 |
| SMAD1 | activates | protein | 0.80 |
| FAM134C | inhibits | gene | 0.80 |
| GDF15 | interacts_with | protein | 0.80 |
| BMPR2 | interacts_with | gene | 0.70 |
| FGFR3 | interacts_with | gene | 0.70 |
| RSPO3 | interacts_with | gene | 0.70 |
| ATG5 | inhibits | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| BMPR1B | associated_with | gene | 0.60 |
| NOTCH3 | associated_with | gene | 0.60 |
| SMAD1 | associated_with | gene | 0.60 |
| TET2 | associated_with | gene | 0.60 |
| PPP1CB | expressed_in | gene | 0.60 |
| SMAD4 | expressed_in | gene | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||