Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RPL11 |
| Function | encodes an essential ribosomal protein component of the 60S large ribosomal subunit. |
| Molecular Weight | 20 kDa |
| Amino Acids | 178 aa |
| Pathways | ubiquitin-proteasome |
| Ensembl ID | ENSG00000142676 |
| GeneCards | RPL11 |
| Human Protein Atlas | RPL11 |
| rRNA binding | Interacts with 28S and 5.8S rRNA, stabilizing the large subunit structure |
| Peptide bond formation | Part of the catalytic center of the ribosome |
| Translation termination | Participates in the release factor binding site |
| Subunit association | Critical for proper 50S (in bacteria) / 60S (in eukaryotes) assembly |
| Associated Diseases | neurodegeneration |
| Interactions | RPL5, MDM2, DNA |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RPL11["RPL11"]
style RPL11 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
RPL5["RPL5"]
ubiquitin_proteasome(("ubiquitin-proteasome"))
MDM2["MDM2"]
neurodegeneration["neurodegeneration"]
RPL11 -->|"activates"| RPL5
RPL11 -->|"participates_in"| ubiquitin_proteasome
MDM2 -->|"activates"| RPL11
RPL11 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class RPL5 gene
class ubiquitin_proteasome pathway
class MDM2 gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| senescence | participates_in | pathway | 0.60 |
| RPL5 | activates | gene | 0.55 |
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||