gene

MDM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MDM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

530Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

MDM2 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 373 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MDM2
Full Name	MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase
Chromosome	12q15
Protein Type	Ligase
Function	MDM2 is a RING-finger E3 ubiquitin ligase with multiple functions:
Primary Expression	neurons and glia - Higher expression in cortex and hippocampus - Regulated by neuronal activity
Molecular Weight	55 kDa
Amino Acids	491 aa
Pathways	NF-κB
UniProt ID	Q00978
NCBI Gene ID	4193
Ensembl ID	ENSG00000135679
OMIM	164785
GeneCards	MDM2
Human Protein Atlas	MDM2
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	Pmiγ, PMIγ
Interactions	AGING, AKT, AMBRA1, AMPK, AND, APOPTOSIS
KG Connections	530 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MDM2 — AlphaFold Q00978 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MDM2 Gene

gene · 543 words

→

MDM2 Protein

protein · 583 words

→

Pathway Diagram

graph TD
    MDM2["MDM2"]
    MDM2 -->|"inhibits"| Tumor["Tumor"]
    MDM2 -->|"inhibits"| Ms["Ms"]
    MDM2 -->|"target for"| Cancer["Cancer"]
    MDM2 -->|"target for"| Fibrosis["Fibrosis"]
    MDM2 -->|"target for"| Als["Als"]
    MDM2 -->|"regulates"| Glioblastoma["Glioblastoma"]
    BCL2["BCL2"] -->|"inhibits"| MDM2
    BCL2_FAMILY["BCL2 FAMILY"] -->|"inhibits"| MDM2
    AKT["AKT"] -->|"target for"| MDM2
    CASP3["CASP3"] -->|"target for"| MDM2
    PI3K["PI3K"] -->|"target for"| MDM2
    MAPK3["MAPK3"] -->|"target for"| MDM2
    JUN["JUN"] -->|"target for"| MDM2
    GENES["GENES"] -->|"target for"| MDM2

Outgoing (327)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Apoptosis	activates	pathway	1.00
CANCER	therapeutic_target	gene	1.00
Als	activates	disease	1.00
Cancer	activates	disease	0.95
P53	associated_with	protein	0.95
TP53	inhibits	gene	0.92
p53	regulates	entity	0.90
p53	inhibits	protein	0.90
p53	interacts_with	protein	0.90
TP53	interacts_with	gene	0.90
cancer	associated_with	disease	0.90
carcinogenesis	promotes	process	0.85
Inflammation	activates	disease	0.85
Tumor	inhibits	disease	0.85
Tumor	activates	disease	0.85
Als	inhibits	disease	0.85
Aging	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
CANCER	activates	gene	0.80
P53	inhibits	gene	0.80
MITOCHONDRIA	activates	gene	0.80
DNA	activates	gene	0.80
GENES	activates	gene	0.80
Als	regulates	disease	0.75
Neurodegeneration	activates	disease	0.75
Cancer	inhibits	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Parkinson	activates	disease	0.75
Cancer	regulates	disease	0.75
Senescence	regulates	disease	0.75
Tumor	regulates	disease	0.75
immunity	regulates	process	0.75
GENES	inhibits	gene	0.70
Apoptosis	inhibits	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Ferroptosis	activates	pathway	0.70
Cell Cycle	inhibits	pathway	0.70
DNA	regulates	gene	0.70
Autophagy	activates	pathway	0.70
Chaperone	therapeutic_target	pathway	0.70
Wnt	activates	pathway	0.70
P53	interacts_with	gene	0.70
MYC	regulates	gene	0.70
Apoptosis	regulates	pathway	0.70
Ovarian Cancer	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Parkinson	causes	disease	0.65

Incoming (203)

Source	Relation	Type	Str
P53	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
Poly(PR)	modulates	protein	0.90
Pmiγ	binds	compound	0.90
ribosomal proteins L5/L11/L23	inhibits	protein	0.90
PMIγ	binds	drug	0.90
P53	regulates	gene	0.90
ribosomal proteins	activates	protein	0.80
TP53	associated_with	gene	0.80
P53	inhibits	gene	0.80
TP53	inhibits	gene	0.80
ribosomal protein	interacts_with	protein	0.75
ERK	activates	gene	0.70
ribosomal protein L23	inhibits	protein	0.70
NEURODEGENERATION	activates	gene	0.70
PARKINSON	activates	gene	0.70
ribosomal protein L5	inhibits	protein	0.70
ribosomal protein L11	inhibits	protein	0.70
AUTOPHAGY	activates	gene	0.70
ROS	activates	gene	0.70
PTEN	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
P53	therapeutic_target	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
TP53	therapeutic_target	gene	0.70
FERROPTOSIS	activates	gene	0.70
BAX	activates	gene	0.70
BCL2A1	activates	gene	0.60
CASP3	activates	gene	0.60
CASP6	activates	gene	0.60
CEBPB	activates	gene	0.60
MCL1	activates	gene	0.60
CDK4	causes	gene	0.60
GENES	regulates	gene	0.60
DNA	regulates	gene	0.60
AGING	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
AMPK	activates	gene	0.60
WNT	activates	gene	0.60
KRAS	regulates	gene	0.60
MOTOR NEURONS	causes	gene	0.60
BCL2 FAMILY	causes	gene	0.60
P53	associated_with	gene	0.60
BRCA1	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
NR4A1	activates	gene	0.60
GAIN	therapeutic_target	gene	0.60
PUMA	activates	gene	0.60
BID	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What upstream mechanisms trigger p53 activation specifically in response to poly

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.661

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning MDM2 in their description or question text

No additional research found

MDM2

Understanding Entity Pages

Summary

Wiki Pages (2)

MDM2 Gene

MDM2 Protein

Pathway Diagram

Outgoing (327)

Incoming (203)

Targeting Hypotheses (0)

Mentioning Analyses (2)

What upstream mechanisms trigger p53 activation specifically in response to poly

Epigenetic reprogramming in aging neurons

Experiments (0)

Related Papers (0)

Debates (4)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

The abstract shows p53 is a central regulator of C9orf72-mediated neurodegenerat

Epigenetic reprogramming in aging neurons

Related Research