gene

MDM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MDM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

537Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

MDM2 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 373 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	MDM2
Full Name	MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase
Chromosome	12q15
Protein Type	Ligase
Function	MDM2 is a RING-finger E3 ubiquitin ligase with multiple functions:
Primary Expression	neurons and glia - Higher expression in cortex and hippocampus - Regulated by neuronal activity
Molecular Weight	55 kDa
Amino Acids	491 aa
Pathways	NF-κB
UniProt ID	Q00978
NCBI Gene ID	4193
Ensembl ID	ENSG00000135679
OMIM	164785
GeneCards	MDM2
Human Protein Atlas	MDM2
Associated Diseases	AGING, ALS, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	PMIγ, Pmiγ
Interactions	SIRT1, GRB2, UBC, ATM, UBIQUITIN, RAF1
KG Connections	537 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MDM2 — AlphaFold Q00978 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MDM2["MDM2"]
    MDM2 -->|"inhibits"| Tumor["Tumor"]
    MDM2 -->|"inhibits"| Ms["Ms"]
    MDM2 -->|"target for"| Cancer["Cancer"]
    MDM2 -->|"target for"| Fibrosis["Fibrosis"]
    MDM2 -->|"target for"| Als["Als"]
    MDM2 -->|"regulates"| Glioblastoma["Glioblastoma"]
    BCL2["BCL2"] -->|"inhibits"| MDM2
    BCL2_FAMILY["BCL2 FAMILY"] -->|"inhibits"| MDM2
    AKT["AKT"] -->|"target for"| MDM2
    CASP3["CASP3"] -->|"target for"| MDM2
    PI3K["PI3K"] -->|"target for"| MDM2
    MAPK3["MAPK3"] -->|"target for"| MDM2
    JUN["JUN"] -->|"target for"| MDM2
    GENES["GENES"] -->|"target for"| MDM2

Outgoing (333)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
Apoptosis	activates	pathway	1.00
CANCER	therapeutic_target	gene	1.00
Als	activates	disease	1.00
Cancer	activates	disease	0.95
P53	binds_to	protein	0.95
TP53	inhibits	gene	0.92
cancer	associated_with	disease	0.90
p53	regulates	entity	0.90
p53	interacts_with	protein	0.90
TP53	interacts_with	gene	0.90
carcinogenesis	promotes	process	0.85
Tumor	inhibits	disease	0.85
Als	therapeutic_target	disease	0.85
Als	inhibits	disease	0.85
Aging	therapeutic_target	disease	0.85
Tumor	activates	disease	0.85
Inflammation	activates	disease	0.85
P53	inhibits	gene	0.80
MITOCHONDRIA	activates	gene	0.80
CANCER	activates	gene	0.80
DNA	activates	gene	0.80
GENES	activates	gene	0.80
immunity	regulates	process	0.75
Fibrosis	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
Senescence	regulates	disease	0.75
Cancer	regulates	disease	0.75
Tumor	regulates	disease	0.75
Cancer	inhibits	disease	0.75
Parkinson	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
MYC	regulates	gene	0.70
Apoptosis	inhibits	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
DNA	regulates	gene	0.70
Apoptosis	regulates	pathway	0.70
Autophagy	activates	pathway	0.70
Wnt	activates	pathway	0.70
GENES	inhibits	gene	0.70
Cell Cycle	inhibits	pathway	0.70
P53	interacts_with	gene	0.70
Chaperone	therapeutic_target	pathway	0.70
Ferroptosis	activates	pathway	0.70
Ms	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	regulates	disease	0.65
Ms	regulates	disease	0.65

Incoming (204)

Source	Relation	Type	Str
P53	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
PMIγ	binds	drug	0.90
Pmiγ	binds	compound	0.90
P53	regulates	gene	0.90
TP53	binds	gene	0.80
ribosomal proteins	activates	protein	0.80
TP53	inhibits	gene	0.80
P53	inhibits	gene	0.80
ribosomal protein	interacts_with	protein	0.75
PI3K	therapeutic_target	gene	0.70
TP53	associated_with	gene	0.70
TP53	therapeutic_target	gene	0.70
PTEN	activates	gene	0.70
BAX	activates	gene	0.70
ERK	activates	gene	0.70
P53	therapeutic_target	gene	0.70
AUTOPHAGY	activates	gene	0.70
FERROPTOSIS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
PARKINSON	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
ROS	activates	gene	0.70
BCL2	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
CDK4	associated_with	gene	0.60
RB1	regulates	gene	0.60
EBF3	regulates	gene	0.60
MYC	regulates	gene	0.60
MTOR	therapeutic_target	gene	0.60
PHOX2B	therapeutic_target	gene	0.60
BIRC5	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
FOS	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
RELA	therapeutic_target	gene	0.60
TP53	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
BAX	expressed_in	gene	0.60
FYN	expressed_in	gene	0.60
VCP	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MDM2

Understanding Entity Pages

Summary

Wiki Pages (21)

MDM2 Gene

cbs-psp-daily-action-plan

NPM1 Gene

FOXO1 Protein

Cellular Senescence in Neurodegeneration

Longevity and Rejuvenation Therapies Landscape

AMPA Receptor Neurons

Cellular Senescence in Neurodegeneration

PKR Pathway in Neurodegeneration

Apoptosis in Neurodegeneration

TEAD1 — TEA Domain Transcription Factor 1

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

RPL10 — Ribosomal Protein L10

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

WEE1 Protein (WEE1 Kinase)

POLD1

RPS10 Gene - Ribosomal Protein S10

CDKN2A Protein

IMPDH1 Protein

RPL27A — Ribosomal Protein L27A