ubiquitin-proteasome

Understanding Entity Pages

This page aggregates everything SciDEX knows about ubiquitin-proteasome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    ubiquitin_proteasome["ubiquitin-proteasome"] -->|"mediates"| protein_misfolding["protein misfolding"]
    style protein_misfolding fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ubiquitin_proteasome["ubiquitin-proteasome"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ubiquitin_proteasome["ubiquitin-proteasome"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ubiquitin_proteasome["ubiquitin-proteasome"] -->|"active in"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ubiquitin_proteasome["ubiquitin-proteasome"] -->|"active in"| blood_brain_barrier["blood-brain barrier"]
    style blood_brain_barrier fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ubiquitin_proteasome["ubiquitin-proteasome"] -->|"mediates"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ubiquitin_proteasome["ubiquitin-proteasome"] -->|"mediates"| pyroptosis["pyroptosis"]
    style pyroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NBR1["NBR1"] -->|"participates in"| ubiquitin_proteasome["ubiquitin-proteasome"]
    style NBR1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    OPTN["OPTN"] -->|"participates in"| ubiquitin_proteasome["ubiquitin-proteasome"]
    style OPTN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CALCOCO2["CALCOCO2"] -->|"participates in"| ubiquitin_proteasome["ubiquitin-proteasome"]
    style CALCOCO2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SQSTM1["SQSTM1"] -->|"participates in"| ubiquitin_proteasome["ubiquitin-proteasome"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"participates in"| ubiquitin_proteasome["ubiquitin-proteasome"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ubiquitin_proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold