Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about S1PR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
S1PR1["S1PR1"]
S1PR1 -->|"regulates"| Macrophage_Polarization["Macrophage Polarization"]
S1PR1 -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
S1PR1 -->|"activates"| M2_Phenotype["M2 Phenotype"]
S1PR1 -->|"upregulates"| PU_1["PU.1"]
S1PR1 -->|"upregulates"| IRF8["IRF8"]
S1PR1 -->|"activates"| LXR["LXR"]
S1PR1 -->|"mediates"| Macrophage_Polarization_To_M2_["Macrophage Polarization To M2 Phenotype"]
S1P["S1P"] -->|"binds_to"| S1PR1| Target | Relation | Type | Str |
|---|---|---|---|
| glial cell activation | promotes | process | 0.90 |
| STAT3 | phosphorylates | protein | 0.88 |
| GFAP | upregulates | protein | 0.85 |
| IL-1β | promotes | protein | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||