concept

S1PR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about S1PR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

1Hypotheses

1Analyses

8Outgoing

5Incoming

0Experiments

1Debates

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💡 Concept Info

Name	S1PR1
Key Genes/Proteins	GFAP, IL-1β, STAT3
Related Diseases	blood_brain_barrier

🔮 Predicted Structure: S1PR1 — AlphaFold P21453 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

S1PR1 (Sphingosine-1-Phosphate Receptor 1) Protein

protein · 1897 words

→

Pathway Diagram

graph TD
    S1PR1["S1PR1"]
    S1PR1 -->|"regulates"| Macrophage_Polarization["Macrophage Polarization"]
    S1PR1 -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    S1PR1 -->|"activates"| M2_Phenotype["M2 Phenotype"]
    S1PR1 -->|"upregulates"| PU_1["PU.1"]
    S1PR1 -->|"upregulates"| IRF8["IRF8"]
    S1PR1 -->|"activates"| LXR["LXR"]
    S1PR1 -->|"mediates"| Macrophage_Polarization_To_M2_["Macrophage Polarization To M2 Phenotype"]
    S1P["S1P"] -->|"binds_to"| S1PR1

Outgoing (8)

Target	Relation	Type	Str
glial cell activation	promotes	process	0.90
STAT3	phosphorylates	protein	0.88
IL-1β	promotes	protein	0.85
GFAP	upregulates	protein	0.85
blood_brain_barrier	associated_with	phenotype	0.70
immune cell trafficking	controls	process	0.70
blood-spinal cord barrier	maintains	structure	0.70
immune cell trafficking	associated_with	phenotype	0.70

Incoming (5)

Source	Relation	Type	Str
proteins-s1pr1-protein	describes	wiki	1.00
S1P	binds_to	metabolite	0.92
Fingolimod	associated_with	drug	0.90
siponimod	associated_with	drug	0.90
Cp1P	activates	receptor	0.85

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sphingosine-1-Phosphate Gradient Disruption	0.455	neuroinflammation	Why do clinical manifestations overlap d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do clinical manifestations overlap despite distinct underlying etiologies in

neuroinflammation | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract notes that clinical presentations overlap across different myelopat

closed · Rounds: 4 · Score: 0.86 · 2026-04-09

Related Research

Hypotheses and analyses mentioning S1PR1 in their description or question text

No additional research found