concept

GLIAL CELL ACTIVATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLIAL CELL ACTIVATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

150Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GLIAL CELL ACTIVATION
Key Genes/Proteins	ALS
Related Diseases	Als, Alzheimer, Dementia, Ms, Tumor

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLIAL_CELL_ACTIVATION["GLIAL CELL ACTIVATION"]
    GLIAL_CELL_ACTIVATION -->|"causes"| Neuroinflammation["Neuroinflammation"]
    GLIAL_CELL_ACTIVATION -->|"modulates"| Mitochondrial_Function["Mitochondrial Function"]
    GLIAL_CELL_ACTIVATION -->|"target for"| Als["Als"]
    GLIAL_CELL_ACTIVATION -->|"activates"| tau_pathology["tau pathology"]
    GLIAL_CELL_ACTIVATION -->|"activates"| Alzheimer["Alzheimer"]
    GLIAL_CELL_ACTIVATION -->|"activates"| Dementia["Dementia"]
    GLIAL_CELL_ACTIVATION -->|"activates"| Ms["Ms"]
    GLIAL_CELL_ACTIVATION -->|"activates"| Tumor["Tumor"]
    MAPK1["MAPK1"] -->|"activates"| GLIAL_CELL_ACTIVATION
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"activates"| GLIAL_CELL_ACTIVATION
    AND["AND"] -->|"inhibits"| GLIAL_CELL_ACTIVATION
    APP["APP"] -->|"inhibits"| GLIAL_CELL_ACTIVATION
    MTORC1["MTORC1"] -->|"activates"| GLIAL_CELL_ACTIVATION
    ALZHEIMER["ALZHEIMER"] -->|"activates"| GLIAL_CELL_ACTIVATION
    AMYLOID["AMYLOID"] -->|"inhibits"| GLIAL_CELL_ACTIVATION
    TFEB["TFEB"] -->|"activates"| GLIAL_CELL_ACTIVATION
    ALS["ALS"] -->|"target for"| GLIAL_CELL_ACTIVATION

Outgoing (104)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.75
ALS	associated_with	gene	0.70
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Dementia	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
AKT	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
APP	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
MTORC1	activates	gene	0.60
TFEB	activates	gene	0.60
Autophagy	activates	pathway	0.60
Akt	activates	pathway	0.60
Complement	activates	pathway	0.60
Mtor	activates	pathway	0.60
Mapk	activates	pathway	0.60
CYTOKINES	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
Inflammasome	therapeutic_target	pathway	0.60
NEUROTOXICITY	activates	gene	0.60
TNF	activates	gene	0.60
CYTOKINES	activates	gene	0.60
NF-ΚB	activates	gene	0.60
TNF-Α	activates	gene	0.60
ALS	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
OPTN	activates	gene	0.60
SOD1	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
NEURON	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60

Incoming (46)

Source	Relation	Type	Str
MAPK1	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
AND	inhibits	gene	0.60
APP	inhibits	gene	0.60
MTORC1	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
TFEB	activates	gene	0.60
ALS	therapeutic_target	gene	0.60
AND	activates	gene	0.60
MOTOR NEURONS	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
TAU	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
GENES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
AIF	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-1	activates	gene	0.60
IL-18	activates	gene	0.60
GFAP	activates	gene	0.60
NLRP3	activates	gene	0.60
DEMENTIA	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
AKT	inhibits	gene	0.60
TNF	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
Alzheimer'S Disease	activates	disease	0.50
Neuroinflammatory	activates	pathway	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
IL-1Β	activates	protein	0.50
NF-κB	activates	concept	0.50
TNF-α	activates	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLIAL CELL ACTIVATION

Understanding Entity Pages

Wiki Pages (20)

NPAS3 Gene

cGAS-STING Signaling in Parkinson's Disease

SOD1 Superoxide Dismutase 1 ALS Causal Chain

Neuroinflammation in Alzheimer and Parkinson Disease

PLAU Gene (Urokinase)

Neuroinflammation and Microglia Pathway

Shanghai Jiao Tong University

cGAS-STING Pathway in Neurodegeneration

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

BMPR2 Gene

Mitochondrial Dysfunction Hub

University of Salento

GADD45G as Pathological Sensor: Orchestrating Reactive Gliosis in Neurodegeneration

RIPK2 (Receptor-Interacting Serine/Threonine-Protein Kinase 2)

Cathepsin K

IL25 (Interleukin 25)

Calcineurin Protein (PPP3CA)

IL20 (Interleukin 20)