Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FINGOLIMOD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | FINGOLIMOD |
| Key Genes/Proteins | STING, NLRP3, BDNF, PD1 |
| Related Diseases | CERAMIDE, NEUROINFLAMMATION, ALZHEIMER |
| Related Pathways | NLRP3 INFLAMMASOME |
Knowledge base pages for this entity
graph TD
FINGOLIMOD["FINGOLIMOD"]
FINGOLIMOD -->|"treats"| Ischemic_Brain_Injury["Ischemic Brain Injury"]
FINGOLIMOD -->|"inhibits"| HMGB1_TLR4_NF__B_Signaling_Pat["HMGB1/TLR4/NF-kappaB Signaling Pathway"]
FINGOLIMOD -->|"downregulates"| IL_1_["IL-1beta"]
FINGOLIMOD -->|"downregulates"| IL_6["IL-6"]
FINGOLIMOD -->|"downregulates"| TNF__["TNF-alpha"]
FINGOLIMOD -->|"inhibits"| S1P_RECEPTOR["S1P RECEPTOR"]
FINGOLIMOD -->|"inhibits"| T_Cell_Infiltration["T Cell Infiltration"]
FINGOLIMOD -->|"treats"| Neuroinflammation["Neuroinflammation"]
Bezafibrate["Bezafibrate"] -->|"interacts"| FINGOLIMOD
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"inhibits"| FINGOLIMOD
CD4["CD4"] -->|"inhibits"| FINGOLIMOD
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"metabolizes"| FINGOLIMOD| Target | Relation | Type | Str |
|---|---|---|---|
| STING | inhibits | gene | 0.65 |
| STING | treats | gene | 0.65 |
| MICROGLIA | inhibits | cell_type | 0.65 |
| MICROGLIA | targets | cell_type | 0.65 |
| NLRP3 INFLAMMASOME | inhibits | pathway | 0.65 |
| NLRP3 | inhibits | gene | 0.65 |
| BDNF | causes | gene | 0.65 |
| CERAMIDE | encodes | phenotype | 0.65 |
| NEUROINFLAMMATION | inhibits | phenotype | 0.56 |
| PD1 | associated_with | gene | 0.50 |
| MICROGLIA | associated_with | cell_type | 0.45 |
| NEURONS | associated_with | cell_type | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| CERAMIDE | associated_with | phenotype | 0.45 |
| IBUDILAST | associated_with | drug | 0.45 |
| NLRP3 | associated_with | gene | 0.45 |
| TREM2 | associated_with | gene | 0.45 |
| BDNF | associated_with | gene | 0.45 |
| STRIATUM | associated_with | brain_region | 0.45 |
| ASTROCYTE | associated_with | cell_type | 0.45 |
| NEURON | inhibits | cell_type | 0.35 |
| MICROGLIA | therapeutic_target | cell_type | 0.35 |
| HIPPOCAMPUS | activates | brain_region | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NLRP3 INFLAMMASOME | activates | pathway | 0.65 |
| NLRP3 | treats | gene | 0.65 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| CERAMIDE | associated_with | phenotype | 0.45 |
| MINOCYCLINE | associated_with | drug | 0.45 |
| TRAUMATIC BRAIN INJURY | associated_with | disease | 0.45 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| MULTIPLE SCLEROSIS | associated_with | disease | 0.45 |
| METABOLIC REPROGRAMMING | associated_with | phenotype | 0.45 |
| SPHINGOMYELIN | associated_with | phenotype | 0.45 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | disease | 0.45 |
| DIMETHYL FUMARATE | associated_with | drug | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| ALPHA-SYNUCLEIN | inhibits | gene | 0.35 |
| CD4 | inhibits | gene | 0.35 |
| ALZHEIMER'S DISEASE | metabolizes | disease | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||