Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Obesity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Obesity is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Aging, Als, Alzheimer. Connected to 1157 entities in the SciDEX knowledge graph.
| Associated Genes | RB1, MAF, MC4R, GENES, ACHE, GAIN, ARNT, BMAL1 |
| Therapeutic Agents | Tirzepatide, Lycorine, Postbiotics |
| KG Connections | 1617 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Obesity["Obesity"] -->|"associated"| Alzheimer_s_disease["Alzheimer's disease"]
Obesity["Obesity"] -->|"associated"| Depression["Depression"]
Obesity["Obesity"] -->|"activates"| Epigenetic["Epigenetic"]
Obesity["Obesity"] -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
Obesity["Obesity"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
Obesity["Obesity"] -->|"regulates"| Sleep_Wake["Sleep-Wake"]
CERS2["CERS2"] -->|"regulates"| Obesity["Obesity"]
JUN["JUN"] -->|"activates"| Obesity["Obesity"]
BMAL1["BMAL1"] -->|"regulates"| Obesity["Obesity"]
CLOCK["CLOCK"] -->|"therapeutic target"| Obesity["Obesity"]
style Obesity fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Diabetes | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Lipid Metabolism | regulates | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Insulin Resistance | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Insulin Resistance | associated_with | disease | 1.00 |
| Diabetes | regulates | disease | 1.00 |
| Type 2 Diabetes | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Microrna | regulates | pathway | 1.00 |
| Oxidative Phosphorylation | activates | pathway | 1.00 |
| Lipid Metabolism | implicated_in | pathway | 1.00 |
| Type 2 Diabetes | regulates | disease | 0.95 |
| Inflammation | inhibits | disease | 0.95 |
| Type 2 Diabetes | therapeutic_target | disease | 0.95 |
| Diabetes | activates | disease | 0.95 |
| Als | therapeutic_target | disease | 0.95 |
| Autolysosomal Dysfunction | causes | process | 0.95 |
| Cardiovascular Ageing | associated_with | process | 0.95 |
| Breast Cancer | risk_factor_for | disease | 0.95 |
| Lysosomal Dysfunction | causes | mechanism | 0.95 |
| MAFLD | risk_factor_for | disease | 0.95 |
| Cognitive Decline | causes | phenotype | 0.95 |
| Memory Dysfunction | causes | phenotype | 0.95 |
| Cellular Senescence | associated_with | process | 0.90 |
| Alzheimer's Disease | risk_factor_for | disease | 0.90 |
| Depression | risk_factor_for | disease | 0.90 |
| Cardiovascular Disease | risk_factor_for | disease | 0.90 |
| OXIDATIVE STRESS | causes | process | 0.90 |
| Alzheimer'S Disease | risk_factor_for | disease | 0.90 |
| Neuroinflammation | causes | process | 0.90 |
| Hippocampal Neurogenesis | associated_with | process | 0.90 |
| Synaptogenesis | associated_with | process | 0.90 |
| Epigenetic | therapeutic_target | pathway | 0.90 |
| Microbiota | activates | pathway | 0.90 |
| Apoptosis | activates | pathway | 0.90 |
| Cholesterol | regulates | pathway | 0.90 |
| Mitochondrial Function | activates | pathway | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Diabetes | associated_with | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| INSULIN RESISTANCE | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| INSULIN RESISTANCE | associated_with | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| DIABETES MELLITUS | associated_with | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| AGING | regulates | gene | 1.00 |
| INFLAMMATION | causes | gene | 1.00 |
| ATP | activates | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| MICRORNAS | regulates | gene | 1.00 |
| CYTOKINES | regulates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| INFLAMMATION | implicated_in | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| INFLAMMATION | contributes_to | gene | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| Metabolic Syndrome | associated_with | disease | 1.00 |
| OVERVIEW | implicated_in | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||