Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| mitophagy | activates | process | 0.70 |
| Alzheimer's disease | associated_with_microglial_priming | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Short-Chain Fatty Acids | activates | metabolite | 0.80 |
| h-48775971 | targets | hypothesis | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biase | 0.525 | neurodegeneration | Do SCFAs directly modulate α-synuclein a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinso [PMID:41761283] | Liu Z, Nie J, Li Y, Huang M, Chen Z et a | Transl Neurodegener | 2026 | 0 |
| Gut Microbiota-Derived Lipopolysaccharides and Short-Chain Fatty Acids Regulate [PMID:41031863] | Maruyama D, Doan TNM, Tian X, Chaki T, Y | Ann N Y Acad Sci | 2025 | 0 |
| Lychee (Litchi chinensis Sonn.) Pulp Phenolics Activate the Short-Chain Fatty Ac [PMID:33533603] | Huang G, Wang Z, Wu G, Zhang R, Dong L e | J Agric Food Chem | 2021 | 0 |