Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SERINE PALMITOYLTRANSFERASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SERINE PALMITOYLTRANSFERASE |
| Molecular Weight | 53 kDa |
| Amino Acids | 473 aa |
| Pathways | Sphingolipid |
| Interactions | SPTLC1 |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SERINE_PALMITOYLTRANSFERASE["SERINE PALMITOYLTRANSFERASE"]
SERINE_PALMITOYLTRANSFERASE -->|"involved_in"| SPTLC1["SPTLC1"]
SERINE_PALMITOYLTRANSFERASE -->|"inhibits"| CERAMIDE["CERAMIDE"]
SERINE_PALMITOYLTRANSFERASE -->|"causes"| Sphingolipid["Sphingolipid"]
SERINE_PALMITOYLTRANSFERASE -->|"expressed in"| Genes["Genes"]
SERINE_PALMITOYLTRANSFERASE -->|"interacts"| MONOCYTE["MONOCYTE"]
SPTLC1 -->|"causes"| SERINE_PALMITOYLTRANSFERASE
CERS2["CERS2"] -->|"regulates"| SERINE_PALMITOYLTRANSFERASE
ABCA1["ABCA1"] -->|"regulates"| SERINE_PALMITOYLTRANSFERASE
SPTLC2["SPTLC2"] -->|"regulates"| SERINE_PALMITOYLTRANSFERASE| Target | Relation | Type | Str |
|---|---|---|---|
| CERAMIDE | inhibits | concept | 0.50 |
| Sphingolipid | causes | pathway | 0.50 |
| Sphingolipid | expressed_in | pathway | 0.50 |
| CERAMIDE | regulates | concept | 0.50 |
| Sphingolipid | regulates | pathway | 0.50 |
| MONOCYTE | interacts_with | concept | 0.50 |
| atherosclerosis | inhibits | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||