disease

atherosclerosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about atherosclerosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2103Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	COL1A1, IBSP, CTSD, SQSTM1, P2RY12, LC3, APOA1, ATP
Therapeutic Agents	ZeXieYin formula, melatonin, MCL, Shexiang Baoxin pill, P2RY12 inhibition
KG Connections	233 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    atherosclerosis["atherosclerosis"] -->|"causes"| cardiovascular_disease["cardiovascular_disease"]
    style cardiovascular_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ZeXieYin_formula["ZeXieYin formula"] -->|"treats"| atherosclerosis["atherosclerosis"]
    style ZeXieYin_formula fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    TNF["TNF"] -->|"risk factor for"| atherosclerosis["atherosclerosis"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MCL["MCL"] -->|"treats"| atherosclerosis["atherosclerosis"]
    style MCL fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    EndMT["EndMT"] -->|"promotes"| atherosclerosis["atherosclerosis"]
    style EndMT fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ferroptosis["ferroptosis"] -->|"promotes"| atherosclerosis["atherosclerosis"]
    style ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style atherosclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (596)

Target	Relation	Type	Str
cardiovascular_disease	causes	disease	0.72
AUTOPHAGOSOME	activates	concept	0.50
HSPG2	regulates	concept	0.50
ISCHEMIC	interacts_with	concept	0.50
ISCHEMIC STROKE	interacts_with	concept	0.50
OBESITY	activates	disease	0.50
INSULIN	activates	concept	0.50
CIRCADIAN CLOCK GENES	activates	concept	0.50
Hypertension	associated_with	disease	0.50
Macrophage	activates	cell_type	0.50
MACROPHAGES	activates	concept	0.50
Macrophage	regulates	cell_type	0.50
Macrophage	inhibits	cell_type	0.50
MACROPHAGES	inhibits	concept	0.50
MACROPHAGES	associated_with	concept	0.50
Proteins	inhibits	protein	0.50
ENDOTHELIAL	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
NEUTROPHIL	activates	cell_type	0.50
disease	interacts_with	disease	0.50
CARDIOVASCULAR DISEASE	interacts_with	concept	0.50
PCSK9	associated_with	concept	0.50
CHOLESTEROL METABOLISM	inhibits	concept	0.50
Macrophage	interacts_with	cell_type	0.50
MICRORNAS	interacts_with	gene	0.50
MACROPHAGES	interacts_with	concept	0.50
MONOCYTES	inhibits	concept	0.50
Macrophage	associated_with	cell_type	0.50
Endothelial Cell	associated_with	cell_type	0.50
Macrophage	expressed_in	cell_type	0.50
MACROPHAGES	expressed_in	concept	0.50
BRAIN INJURY	causes	concept	0.50
disease	causes	disease	0.50
ENDOTHELIAL	causes	concept	0.50
Heart Failure	associated_with	disease	0.50
disease	associated_with	disease	0.50
Coronary Artery Disease	associated_with	disease	0.50
CARDIOVASCULAR DISEASE	associated_with	concept	0.50
CHRONIC INFLAMMATION	activates	concept	0.50
Heart Failure	interacts_with	disease	0.50
Cardiac	regulates	disease	0.50
disease	regulates	disease	0.50
MACROPHAGES	regulates	concept	0.50
Myocardial Infarction	regulates	disease	0.50
CARDIOVASCULAR DISEASE	regulates	concept	0.50
Cardiac	associated_with	disease	0.50
LIPOPHAGY	associated_with	concept	0.50
RIP1	associated_with	concept	0.50
ENDOTHELIAL	activates	concept	0.50
Pyroptosis	inhibits	pathway	0.50

Incoming (1507)

Source	Relation	Type	Str
ZeXieYin formula	treats	drug	0.90
TNF	risk_factor_for	gene	0.90
MCL	treats	drug	0.90
EndMT	promotes	process	0.90
ferroptosis	promotes	process	0.90
Shexiang Baoxin pill	treats	drug	0.90
APRIL	limits	protein	0.90
BaP	associated_with	compound	0.90
PI3K-AKT signaling pathway	promotes	pathway	0.85
APOE	associated_with	gene	0.85
APOE	risk_factor_for	gene	0.85
NRF2	prevents	protein	0.85
STAT3	associated_with	gene	0.85
P2RY12 inhibition	treats	drug	0.85
NLRP3	associated_with	protein	0.82
Porphyromonas gingivalis	causes	pathway	0.80
superoxide anion	causes	phenotype	0.80
MAFF	regulates	protein	0.80
DCLK1	associated_with	gene	0.80
STING pathway	promotes	pathway	0.80
TREM2	associated_with	gene	0.80
CASP1	causes	gene	0.80
heparan sulfate proteoglycans	binds_to	protein	0.80
SPP1	therapeutic_target	gene	0.80
APRIL	inhibits	protein	0.80
diabetes	activates	disease	0.72
foam cell formation	associated_with	process	0.70
melatonin	treats	drug	0.70
COL1A1	associated_with	gene	0.70
IBSP	associated_with	gene	0.70
CTSD	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
PTEN	associated_with	gene	0.65
LDLR	contributes_to	protein	0.64
hypercholesterolemia	contributes_to	disease	0.64
PCSK9	contributes_to	protein	0.64
GPR146	activates	protein	0.64
miR_369_3p	inhibits	gene	0.64
SORLA	associated_with	protein	0.60
high_fat_diet	activates	phenotype	0.56
neutrophils	contributes_to	cell_type	0.56
P2RY12	implicated_in	gene	0.50
LC3	implicated_in	gene	0.50
APOA1	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
PI3K	implicated_in	gene	0.50
MAP1LC3	implicated_in	gene	0.50
ABCG1	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

What determines P2RY12 receptor expression/activity specifically in VSMCs during

neurodegeneration | 2026-04-07 | 0 hypotheses

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

atherosclerosis

Understanding Entity Pages

Wiki Pages (20)

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