concept

CERAMIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CERAMIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections
0Hypotheses
1Analyses
50Outgoing
50Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameCERAMIDE
Key Genes/ProteinsTAU, APP, AMYLOID, APOE
Related DiseasesNEUROINFLAMMATION, MITOCHONDRIAL DYSFUNCTION, AXONAL TRANSPORT, INSULIN RESISTANCE, AGING
Linked Hypotheses7 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Alzheimer's Disease

disease · 5265 words

Frontotemporal Dementia (FTD)

disease · 5230 words

Oligodendrocytes

cell · 4838 words

APOC4 — Apolipoprotein C-IV

gene · 4687 words

Pathway Diagram

flowchart TD
    N0["CERAMIDE"]
    N1["SMPD1"]
    N1 -->|"produces"| N0
    N2["APOE"]
    N2 -->|"treats"| N0
    N3["NEUROINFLAMMATION"]
    N0 -->|"activates"| N3
    N4["ENDOPLASMIC RETICULUM"]
    N0 -->|"regulates"| N4
    N5["TAU"]
    N0 -->|"activates"| N5
    N6["MITOCHONDRIAL DYSFUNCTION"]
    N0 -->|"causes"| N6
    N7["APP"]
    N0 -->|"inhibits"| N7
    N8["AXONAL TRANSPORT"]
    N0 -->|"inhibits"| N8
    N9["INSULIN RESISTANCE"]
    N0 -->|"activates"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 gene
    class N2 gene
    class N3 phenotype
    class N5 protein
    class N6 phenotype
    class N7 gene
    class N8 phenotype
    class N9 phenotype

Outgoing (102)

TargetRelationTypeStr
NEUROINFLAMMATIONactivatesphenotype0.70
TAUactivatesprotein0.70
MITOCHONDRIAL DYSFUNCTIONcausesphenotype0.70
APPinhibitsgene0.70
AXONAL TRANSPORTinhibitsphenotype0.70

Incoming (98)

SourceRelationTypeStr
APOEtreatsgene0.70
APOEactivatesgene0.70
APOEinhibitsgene0.70
ENDOPLASMIC RETICULUM STRESScausesphenotype0.70
APPtreatsgene0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the therapeutic window between GCS inhibition efficacy and systemic toxi

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found