protein

STMN2PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about STMN2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Stathmin 2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	STMN2PROTEIN
Full Name	Stathmin-2
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
UniProt ID	Search UniProt
GeneCards	STMN2PROTEIN
Human Protein Atlas	STMN2PROTEIN
Stathmin-like domain (SLD)	The C-terminal region binds directly to α/β-tubulin heterodimers, preventing microtubule polymerization. This domain is highly conserved across the stathmin family.
C-terminal tail	Mediates protein-protein interactions and subcellular localization.
Axonal growth during development	High STMN2 expression promotes axonal extension by creating a permissive microtubule environment in growth cones.
Neuronal plasticity	Regulates microtubule dynamics in dendritic spines and presynaptic terminals, affecting synaptic plasticity.
Nerve injury response	Dramatically upregulated after peripheral nerve injury, promoting axonal regeneration<sup>[6]</sup>.
Signal transduction	Acts as a downstream effector of multiple neuronal signaling pathways.
Developing nervous system	High expression during embryonic and postnatal development
Adult brain	Moderate expression in cortical neurons, hippocampal pyramidal cells, and motor neurons
Associated Diseases	ALS, frontotemporal dementia, neurodegeneration
Interactions	Actin, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ATP, AXON REGENERATION
SciDEX Hypotheses	STMN2 Restoration as a Prerequisite for Axon Growt
KG Connections	118 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: STMN2PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Stathmin-2 Protein

protein · 800 words

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Pathway Diagram

graph TD
    STMN2PROTEIN["STMN2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    STMN2PROTEIN -->|"implicated_in"| neurodegeneration
    style STMN2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

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Related Research

Hypotheses and analyses mentioning STMN2PROTEIN in their description or question text

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