Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNGR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYNGR3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in, associated with. Associated with Als, Dementia, Ms. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | SYNGR3 |
| Full Name | Synaptophysin-3 / Synaptogyrin-3 |
| Chromosome | 16p13.2 |
| Function | is a member of the synaptogyrin family of synaptic vesicle proteins. |
| Primary Expression | presynaptic terminals and is involved in synaptic vesicle organization and function[@hubler2004][@takamori2006] |
| NCBI Gene ID | SYNGR3 Gene |
| Ensembl ID | ENSG00000134152 |
| GeneCards | SYNGR3 |
| Human Protein Atlas | SYNGR3 |
| Full name | Synaptophysin-3 / Synaptogyrin-3 |
| Encoded protein | SYNGR3 Protein (synaptophysin-3) |
| Related pathways | Synaptic Vesicle Trafficking, Protein Aggregation, Alpha-Synucleinopathy |
| Associated Diseases | neurodegeneration |
| Interactions | GFAP, CRYAB, PARKINSON'S DISEASE, ALPHA-SYNUCLEIN, NEURODEGENERATIVE DISEASES |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
SYNGR3["<b>SYNGR3</b>"]
Parkinson{"Parkinson"}
SYNGR3 -->|"interacts with"| Parkinson
Als{"Als"}
SYNGR3 -->|"interacts with"| Als
Dementia{"Dementia"}
SYNGR3 -->|"interacts with"| Dementia
Ms{"Ms"}
SYNGR3 -->|"interacts with"| Ms
neurodegeneration["neurodegeneration"]
SYNGR3 -->|"implicated in"| neurodegeneration
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"interacts with"| SYNGR3
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
ALPHA_SYNUCLEIN -->|"interacts with"| SYNGR3
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"interacts with"| SYNGR3
GFAP["GFAP"]
GFAP -->|"interacts with"| SYNGR3
CRYAB["CRYAB"]
CRYAB -->|"interacts with"| SYNGR3
HSPA8["HSPA8"]
HSPA8 -->|"associated with"| SYNGR3
style SYNGR3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| GFAP | interacts_with | gene | 0.60 |
| CRYAB | interacts_with | gene | 0.60 |
| HSPA8 | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | interacts_with | gene | 0.60 |
| ALPHA-SYNUCLEIN | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||