gene

SYNGR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNGR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections
0Hypotheses
0Analyses
4Outgoing
6Incoming
0Experiments

Summary

SYNGR3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in, associated with. Associated with Als, Dementia, Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSYNGR3
Full NameSynaptophysin-3 / Synaptogyrin-3
Chromosome16p13.2
Functionis a member of the synaptogyrin family of synaptic vesicle proteins.
Primary Expressionpresynaptic terminals and is involved in synaptic vesicle organization and function[@hubler2004][@takamori2006]
NCBI Gene IDSYNGR3 Gene
Ensembl IDENSG00000134152
GeneCardsSYNGR3
Human Protein AtlasSYNGR3
Full nameSynaptophysin-3 / Synaptogyrin-3
Encoded proteinSYNGR3 Protein (synaptophysin-3)
Related pathwaysSynaptic Vesicle Trafficking, Protein Aggregation, Alpha-Synucleinopathy
Associated Diseasesneurodegeneration
InteractionsGFAP, CRYAB, PARKINSON'S DISEASE, ALPHA-SYNUCLEIN, NEURODEGENERATIVE DISEASES
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SYNGR3 Gene

gene · 692 words

SYNAPTOGENIN — Synaptogyrin Family

gene · 2576 words

Pathway Diagram

graph TD
    SYNGR3["<b>SYNGR3</b>"]
    Parkinson{"Parkinson"}
    SYNGR3 -->|"interacts with"| Parkinson
    Als{"Als"}
    SYNGR3 -->|"interacts with"| Als
    Dementia{"Dementia"}
    SYNGR3 -->|"interacts with"| Dementia
    Ms{"Ms"}
    SYNGR3 -->|"interacts with"| Ms
    neurodegeneration["neurodegeneration"]
    SYNGR3 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| SYNGR3
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"interacts with"| SYNGR3
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| SYNGR3
    GFAP["GFAP"]
    GFAP -->|"interacts with"| SYNGR3
    CRYAB["CRYAB"]
    CRYAB -->|"interacts with"| SYNGR3
    HSPA8["HSPA8"]
    HSPA8 -->|"associated with"| SYNGR3
    style SYNGR3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

TargetRelationTypeStr
Parkinsoninteracts_withdisease0.65
Alsinteracts_withdisease0.65
Dementiainteracts_withdisease0.65
Msinteracts_withdisease0.65

Incoming (6)

SourceRelationTypeStr
GFAPinteracts_withgene0.60
CRYABinteracts_withgene0.60
HSPA8associated_withgene0.60
PARKINSON'S DISEASEinteracts_withgene0.60
ALPHA-SYNUCLEINinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found