Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synaptic failure: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| HDAC6 | contributes_to | gene | 0.85 |
| impaired axonal transport | mediates | process | 0.85 |
| MAPT | causes | gene | 0.80 |
| Dna Methylation Clocks | associated_with | biomarker | 0.80 |
| HDAC inhibitors | treats | drug | 0.80 |
| TDP-43 cytoplasmic accumulation | causes | process | 0.70 |
| tripartite synapse dysfunction | causes (coordinated dysfunction across astrocyte-microglia) | mechanism | 0.70 |
| Tau | contributes_to | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE4-driven loss of neuronal PI(4,5)P2 bridges ganglioside- | 0.380 | alzheimer | Lipid metabolism dysregulation and membr |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.680
neurodegeneration | 2026-04-03 | 12 hypotheses Top: 0.726
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning Synaptic failure in their description or question text
No additional research found