Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HDAC INHIBITORS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HDAC INHIBITORS |
| Summary | Page for HDAC Inhibitors |
Knowledge base pages for this entity
graph TD
HDAC_INHIBITORS["HDAC INHIBITORS"]
HDAC_INHIBITORS -->|"inhibits"| HDAC["HDAC"]
HDAC_INHIBITORS -->|"modulates"| Histone_Acetylation["Histone Acetylation"]
HDAC_INHIBITORS -->|"upregulates"| ATP2A3["ATP2A3"]
HDAC_INHIBITORS -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
HDAC_INHIBITORS -->|"inhibits"| Amyloid_Beta_Plaque_Formation["Amyloid Beta Plaque Formation"]
HDAC_INHIBITORS -->|"treats"| Neurological_Diseases["Neurological Diseases"]
HDAC_INHIBITORS -->|"modulates"| Chromatin_Remodeling["Chromatin Remodeling"]
HDAC_INHIBITORS -->|"inhibits"| Tau_Protein_Phosphorylation["Tau Protein Phosphorylation"]| Target | Relation | Type | Str |
|---|---|---|---|
| Histone Acetylation | modulates | process | 0.90 |
| Alzheimer'S Disease | treats | disease | 0.90 |
| Amyloid Beta | associated_with | protein | 0.90 |
| ATP2A3 | upregulates | gene | 0.88 |
| Neurological Diseases | treats | disease | 0.88 |
| Amyloid Beta Plaque Formation | inhibits | process | 0.85 |
| Neurological Diseases | treats | disease | 0.85 |
| Chromatin Remodeling | modulates | process | 0.85 |
| TAU | downregulates | protein | 0.85 |
| Cell Survival | promotes | process | 0.85 |
| Metabolic Homeostasis | associated_with | process | 0.85 |
| Microtubule Stability | promotes | phenotype | 0.85 |
| MAPT | downregulates | protein | 0.85 |
| Metabolic Homeostasis | modulates | process | 0.85 |
| Alzheimer's Disease | treats | disease | 0.85 |
| Cognitive Impairment | associated_with | phenotype | 0.85 |
| Amyloid Beta | inhibits | protein | 0.85 |
| Neuroinflammation | inhibits | process | 0.85 |
| Neuroinflammation | suppresses | process | 0.85 |
| Tau Protein Phosphorylation | inhibits | process | 0.80 |
| Transcriptional Repression | modulates | process | 0.80 |
| Isoform Selectivity | modulates | mechanism | 0.80 |
| Learning and Memory Impairment | treats | phenotype | 0.80 |
| Cell Survival | associated_with | process | 0.80 |
| Microtubule Stability | associated_with | process | 0.80 |
| Gene Expression | upregulates | process | 0.80 |
| EPIGENOME | restores | process | 0.80 |
| Synaptic failure | treats | process | 0.80 |
| Endometrial Carcinoma | treats | disease | 0.80 |
| Osteosarcoma | treats | disease | 0.80 |
| Multiple Myeloma | treats | disease | 0.80 |
| Neuroinflammation | inhibits | process | 0.80 |
| Neurodegenerative Diseases | treats | disease | 0.80 |
| Alzheimer's disease | therapeutic_for | disease | 0.80 |
| Ovarian Cancer | treats | disease | 0.80 |
| Glioma | treats | disease | 0.80 |
| Microtubule Stability | upregulates | process | 0.75 |
| Cell Survival | upregulates | process | 0.75 |
| ALZHEIMER'S DISEASE | treats | disease | 0.75 |
| Blood-Brain Barrier Penetration | modulates | process | 0.70 |
| Nervous System Diseases | treats | disease | 0.70 |
| Blood-Brain Barrier Penetration | associated_with | mechanism | 0.70 |
| SIRT1 | references | gene | 0.40 |
| HDAC | references | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HDAC | therapeutic_target | protein | 0.95 |
| Blood-Brain Barrier Penetration | associated_with | phenotype | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||