gene

HDAC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1133Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Cytoplasmic deacetylase critical for protein quality control, aggresome formation, and autophagy in neurodegenerative diseases

View on Wiki →

🧬 Gene Info

Gene Symbol	HDAC6
Full Name	Histone Deacetylase 6
Chromosome	Xp11.23
Protein Type	Protein
Function	is a unique class IIb histone deacetylase that predominantly localizes to the cytoplasm rather than the nucleus.
Primary Expression	Ubiquitous, highest in brain, liver, kidney
Molecular Weight	131 kDa
Amino Acids	1215 aa
Pathways	AUTOPHAGY, Amyloid, Autophagy, Dna Repair, Inflammasome
UniProt ID	Q9UQR8
NCBI Gene ID	10013
Ensembl ID	ENSG00000094631
GeneCards	HDAC6
Human Protein Atlas	HDAC6
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, CANCER, Cardiovascular
Known Drugs/Compounds	curcumin, lithium, rapamycin
Interactions	SREBF2, PSEN1, KEAP1, NRF2, OPTN, APP
SciDEX Hypotheses	HDAC6 Selective Inhibition to Restore Acetylation HDAC6 Inhibition for Dual Restoration of Microtubu
KG Connections	1133 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HDAC6 — AlphaFold Q9UQR8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HDAC6(["HDAC6"])
    Autophagic_Degradation("Autophagic Degradation")
    P62(["P62"])
    PROTEASOME["PROTEASOME"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    Cancer["Cancer"]
    OPTN(["OPTN"])
    Autophagy["Autophagy"]
    OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
    UBIQUITIN(["UBIQUITIN"])
    Tumor["Tumor"]
    Parkinson["Parkinson"]

    HDAC6 -->|"regulates"| Autophagic_Degradation
    P62 -->|"modulates"| HDAC6
    PROTEASOME -->|"modulates"| HDAC6
    HDAC6 -->|"regulates"| Alzheimer
    HDAC6 -->|"regulates"| Als
    HDAC6 -->|"regulates"| Cancer
    HDAC6 -->|"activates"| Als
    HDAC6 -->|"therapeutic target"| Als
    HDAC6 -->|"interacts with"| OPTN
    HDAC6 -->|"activates"| Autophagy
    HDAC6 -->|"regulates"| OXIDATIVE_STRESS
    HDAC6 -->|"activates"| UBIQUITIN
    HDAC6 -->|"associated with"| Tumor
    HDAC6 -->|"associated with"| Parkinson
    HDAC6 -->|"associated with"| Cancer

    style HDAC6 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (755)

Target	Relation	Type	Str
Macroautophagy	involved_in	process	0.95
Autophagosome-Lysosome Fusion	regulates	process	0.90
Lewy Bodies	component_of	structure	0.90
CTTN	regulates	gene	0.90
Autophagosome-Lysosome Fusion	promotes	process	0.90
neurodegeneration	inhibits	disease	0.90
neurons	expressed_in	cell_type	0.90
Protein Aggregates	degrades	structure	0.85
Parkinson Disease	associated_with	disease	0.85
Tubulin Acetylation	catalyzes	process	0.85
Proteasomal Inhibition	mediates	mechanism	0.85
acetylation	inhibits	process	0.85
Synaptic Failure	contributes_to	process	0.85
Memory Restoration	targets	phenotype	0.82
PIK3C3	regulates	gene	0.80
P62	interacts_with	protein	0.80
Multiple System Atrophy	associated_with	disease	0.80
F-actin cytoskeleton	regulates	pathway	0.80
neuroinflammation	inhibits	disease	0.80
neuroinflammation	regulates	disease	0.80
epigenetic regulation	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
Α-Tubulin	modulates	protein	0.75
TAU	substrate_of	protein	0.75
Alzheimer	regulates	disease	0.75
Als	regulates	disease	0.75
Cancer	regulates	disease	0.75
Als	activates	disease	0.75
Als	therapeutic_target	disease	0.75
OPTN	interacts_with	protein	0.70
UBIQUITIN	activates	gene	0.70
MAP1LC3B	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
MTOR	regulates	gene	0.70
TFEB	regulates	gene	0.70
ULK1	regulates	gene	0.70
TAU	modifies	protein	0.70
neurodegeneration	regulates	disease	0.70
Autophagy	activates	pathway	0.70
OXIDATIVE STRESS	regulates	gene	0.70
Parkinson's disease	activates	disease	0.70
Parkinson's disease	regulates	disease	0.70
apoptosis pathway	participates_in	pathway	0.70
STROKE	inhibits	disease	0.70
Alzheimer's disease	inhibits	disease	0.70
Alzheimer's disease	implicated_in	disease	0.70
TAU	associated_with	gene	0.65
neuroinflammation	co_discussed	concept	0.65

Incoming (378)

Source	Relation	Type	Str
ISG15	inhibits	gene	0.95
SGK1	upregulates	gene	0.90
ISG15	binds	gene	0.90
h-ca454967	targets_gene	hypothesis	0.90
PIK3C3	phosphorylates	protein	0.80
AR	activates	gene	0.70
BACE1	activates	gene	0.70
ATG	activates	gene	0.70
ATG	regulates	gene	0.70
rapamycin	targets	drug	0.70
BDNF	co_discussed	gene	0.65
BACE1	co_discussed	gene	0.65
MAPT	treats	gene	0.65
MAPT	inhibits	gene	0.65
NEK1	causes	gene	0.65
HIPPOCAMPUS	inhibits	brain_region	0.65
NEURODEGENERATION	inhibits	disease	0.65
ACTB	regulates	gene	0.60
CDC42	regulates	gene	0.60
CASP3	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
STK11	associated_with	gene	0.60
VIM	associated_with	gene	0.60
BECN1	regulates	gene	0.60
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
SOX9	associated_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC6 Selective Inhibition to Restore Acetylation Balance an	0.577	structural biology	What is the atomic-resolution structure
HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism	0.537	neurodegeneration	Do SCFAs directly modulate α-synuclein a
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili	0.459	neurodegeneration	Which tau PTMs are both disease-specific

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the atomic-resolution structure of K280-acetylated tau and how does it t

structural biology | 2026-04-13 | 1 hypotheses Top: 0.577

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit ap [PMID:40715275]	Wang H, Yousaf W, Haseeb A, Wang Z, Zhen	Sci Rep	2025
Effect of Calebin-A on Critical Genes Related to NAFLD: A Protein-Protein Intera [PMID:38751599]	Mahmoudi A, Hajihasani MM, Majeed M, Jam	Curr Genomics	2024
HDAC6 as a Prognostic Factor and Druggable Target in HER2-Positive Breast Cancer [PMID:39594707]	Cortesi M, Bravaccini S, Ravaioli S, Pet	Cancers (Basel)	2024
Acute heat stress reduces viability but increases lactate secretion of porcine i [PMID:34392171]	Yang CX, Chen L, Yang YW, Mou Q, Du ZQ	Theriogenology	2021

HDAC6

Understanding Entity Pages

Summary

Wiki Pages (21)

HDAC6 (Redirect)

cbs-psp-daily-action-plan

Novel Therapy Index

Multiple System Atrophy

Autophagy Mechanisms

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Epigenetic Alterations in Alzheimer's Disease

O-GlcNAcase (OGA) Inhibitor Landscape — Programs, Mechanisms, Companies

Transcriptional Regulation in Neurodegeneration

Epigenetic Mechanisms in Alzheimer's Disease

HDAC6 Protein

Histone Modification Pathways in Neurodegeneration

HDAC6 Protein

epigenetics-neurodegeneration

chromatin-remodeling-neurodegeneration

Epigenetic Changes in PSP

4R Tauopathy Mechanisms

Chromatin Remodeling in Neurodegeneration