Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synaptic function / plasticity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP-Mediated Cholinergic Synapse Disruption | 0.564 | neurodegeneration | Senolytic therapy for age-related neurod |
| Sleep Spindle-Synaptic Plasticity Enhancement | 0.491 | neurodegeneration | Sleep disruption as cause and consequenc |
| Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics | 0.424 | neurodegeneration | Synaptic pruning by microglia in early A |
| Trans-Synaptic Adhesion Molecule Modulation | 0.340 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.557
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.503
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056] | Shuliko LM, Svarovsky DA, Spirina LV, Og | Front Biosci (Landmark Ed) | 2025 | 1 |
| CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937] | Diao Y, Hao M, Xie M, Hu X, Tan R, Wang | J Neuroimmunol | 2025 | 1 |
| Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141] | Xie G, Jiang G, Huang L, Sun S, Li X, Wu | CNS Neurosci Ther | 2025 | 1 |
| Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune mi [PMID:39237260] | Hou Z, Lu F, Lin J, Wu Y, Chen L, Fang H | J Immunother Cancer | 2024 | 1 |
| The role of annexins in central nervous system development and disease. [PMID:38639785] | White ZB 2nd, Nair S, Bredel M | J Mol Med (Berl) | 2024 | 1 |
| Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury vi [PMID:37908731] | Zhou H, Yan L, Huang H, Li X, Xia Q, Zhe | Theranostics | 2023 | 1 |
| Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating m [PMID:34022892] | Xu X, Gao W, Li L, Hao J, Yang B, Wang T | J Neuroinflammation | 2021 | 1 |
| Annexin A1: Uncovering the Many Talents of an Old Protein. [PMID:29614751] | Sheikh MH, Solito E | Int J Mol Sci | 2018 | 1 |
| Effects of caffeine on sleep and cognition. [PMID:21531247] | Snel J, Lorist MM | Prog Brain Res | 2011 | 1 |
| Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808] | Kunttas-Tatli E, Bose A, Kahali B, Bisho | Genesis | 2009 | 1 |
| Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858] | ["Soltani T", "Karimian M", "Vaziri H", | Biochemistry and biophysics re | 2026 | 0 |
| Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064] | ["Wang H", "Liu Y", "Jiang K", "Yin J", | Poultry science | 2026 | 0 |
| Fragment merging design, synthesis, and biological evaluation of novel methyl Se [PMID:41785527] | ["Shaaban S", "Hawas S", "Elmaaty A", "B | Bioorganic & medicinal chemist | 2026 | 0 |
| Theranekron modulates extracellular matrix and apoptotic signaling pathways in c [PMID:41852375] | ["Kuccukturk S", "Duran T", "Vanli S", " | Cytotechnology | 2026 | 0 |
| Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers i [PMID:41779471] | ["Cruz-Romero S", "Baldi\u00f3n A", "Taw | Journal of applied oral scienc | 2026 | 0 |
| Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients W [PMID:41659822] | ["Nelson-Taylor S", "Troost J", "Giannin | Kidney medicine | 2026 | 0 |
| Encapsulation of hydroxyurea in exosomes derived from adipose mesenchymal stem c [PMID:41702234] | ["Taheri Kangarshahi Z", "Ganji S", "Ash | Translational oncology | 2026 | 0 |
| NSUN2 promoted tumor growth and metastatic via m [PMID:41794778] | ["Li R", "Jin D", "Shao S", "Guo J"] | Cell death & disease | 2026 | 0 |
| LINC00491 promotes nasopharyngeal carcinoma metastasis by binding to purine-rich [PMID:41903631] | ["Liu Y", "Li H", "Zhang J", "Peng J", " | International journal of biolo | 2026 | 0 |
| GW201 mediates neuroprotection via allosteric modulation of NMDA receptor activi [PMID:41693050] | ["Tiliwaerde M", "Zhaoji D", "Jingjing L | British journal of pharmacolog | 2026 | 0 |