gene

MMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

767Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

MMP2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 317 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	MMP2
Full Name	Matrix Metallopeptidase 2
Chromosome	16q13
Protein Type	Protease
Target Class	Protease
Function	MMP-2 (gelatinase A) degrades gelatin (denatured collagen), type IV collagen, and elastin.
Mechanism of Action	Small molecule zinc-chelating inhibitors of metalloprotease activity
Primary Expression	neurons, astrocytes, microglia, and endothelial cells where it regulates synaptic plasticity, blood-brain
Druggability	Medium (0.46)
Clinical Stage	Phase III
Molecular Weight	73.9 kDa
Amino Acids	660 aa
Pathways	Akt, Amyloid, Nf-Κb, Pi3K, Sleep-Wake Cycle
UniProt ID	P08253
Ensembl ID	ENSG00000196547
GeneCards	MMP2
Human Protein Atlas	MMP2
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease
Known Drugs/Compounds	Melatonin
Interactions	MMP9, TLR4, GFAP, JAK2, STAT3, PTGS2
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	767 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MMP2 — AlphaFold P08253 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MMP2["MMP2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    MMP2["MMP2"] -->|"interacts"| MMP9["MMP9"]
    MMP2["MMP2"] -->|"co discussed"| C3["C3"]
    MMP2["MMP2"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    MMP2["MMP2"] -->|"co discussed"| DNASE2["DNASE2"]
    MMP2["MMP2"] -->|"co discussed"| STING1["STING1"]
    MMP9_1["MMP9"] -->|"interacts"| MMP2["MMP2"]
    MMP9_2["MMP9"] -->|"co discussed"| MMP2["MMP2"]
    SLC7A11["SLC7A11"] -->|"co discussed"| MMP2["MMP2"]
    AQP4["AQP4"] -->|"co discussed"| MMP2["MMP2"]
    style MMP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (444)

Target	Relation	Type	Str
extracellular matrix degradation	mediates	process	0.95
MMP9	co_mentioned_with	gene	0.90
cell migration	promotes	process	0.90
Brain Edema	associated_with	phenotype	0.85
glomerular endothelial ultrastructure	degrades	process	0.85
Cell Migration	promotes	process	0.85
Cancer	therapeutic_target	disease	0.85
Alzheimer's Disease	associated_with	disease	0.85
Breast Cancer	biomarker_for	disease	0.85
Cerebral Cortex	expressed_in	brain_region	0.80
Blood-Brain Barrier Function	associated_with	process	0.80
interstitial fibrosis and tubular atrophy	contributes_to	phenotype	0.80
endothelial barrier integrity	suppresses	process	0.80
Non-Small-Cell Lung Cancer	involved_in	disease	0.80
MMP9	inhibits	gene	0.80
perineuronal nets	degrades	structure	0.80
Blood-Brain Barrier Function	modulates	process	0.75
Tumor	inhibits	disease	0.75
Tumor	activates	disease	0.75
Alzheimer'S Disease	associated_with	disease	0.75
ECM_DEGRADATION	regulates	phenotype	0.72
RAGE	therapeutic_target	gene	0.70
MMP9	treats	gene	0.70
TIMP2	inhibits	gene	0.70
VEGF	expressed_in	gene	0.70
CANCER	therapeutic_target	gene	0.70
Melatonin	involved_in	drug	0.70
NF-kB signaling	participates_in	pathway	0.70
Wnt signaling	participates_in	pathway	0.70
Alzheimer's disease	biomarker_for	disease	0.70
neural stem cells	activates	cell_type	0.70
neural stem cells	interacts_with	cell_type	0.70
Spinal Cord Injury	inhibits	disease	0.65
NRF2	activates	gene	0.65
SIRT1	activates	gene	0.65
RAGE	causes	gene	0.65
RAGE	associated_with	gene	0.65
Ischemia	activates	disease	0.65
Aging	activates	disease	0.65
Stroke	activates	disease	0.65
Cancer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	inhibits	disease	0.65

Incoming (323)

Source	Relation	Type	Str
Timp-1	inhibits	protein	0.90
Hu-Loaded Exosomes	downregulates	compound	0.90
HB68	downregulates	compound	0.90
Litebamine	downregulates	compound	0.90
h-1acdd55e	targets_gene	hypothesis	0.90
Theranekron	downregulates	drug	0.88
NFKB1	upregulates	protein	0.85
cardamom nanoemulsion	downregulates	compound	0.85
FB23	downregulates	drug	0.85
PPARGC1A	inhibits	gene	0.80
h-1acdd55e	targets	hypothesis	0.80
Melatonin	targets	drug	0.80
STAT3	activates	gene	0.70
TIMP2	regulates	gene	0.70
TIMP2	activates	gene	0.70
BAX	activates	gene	0.70
MICROGLIA	activates	cell_type	0.70
MICROGLIA	regulates	cell_type	0.70
APOPTOSIS	regulates	phenotype	0.70
OXIDATIVE STRESS	causes	phenotype	0.70
YAP	regulates	protein	0.68
ALZHEIMER'S DISEASE	associated_with	gene	0.66
NF-KB	associated_with	protein	0.66
NRF2	targets	gene	0.65
ERK	activates	gene	0.65
ERK	phosphorylates	gene	0.65
SENESCENCE	inhibits	phenotype	0.65
KCNK2	regulates	gene	0.64
MMP9	activates	gene	0.60
TRKB	activates	gene	0.60
CD163	biomarker_for	gene	0.60
MMP9	inhibits	gene	0.60
CD14	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
S100A8	inhibits	gene	0.60
CD47	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
TNF	inhibits	gene	0.60
TLR4	activates	gene	0.60
CD68	inhibits	gene	0.60
RAB32	associated_with	gene	0.60
DRP1	associated_with	gene	0.60
GBM	associated_with	gene	0.60
RAGE	therapeutic_target	gene	0.60
SERPINE1	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
IGF1	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MMP2

Understanding Entity Pages

Summary

Wiki Pages (21)

MMP2 Gene

bbb-transport-mechanisms

Section 253: Respiratory Function and Dysphagia Therapy in CBS/PSP

Blood-Brain Barrier Dysfunction Pathway

WWTR1 (TAZ) — WW Domain Containing Transcription Regulator 1, Hippo Effector

RAB32 Gene

MMP9 Protein

KDR Gene

Section 146: Advanced Synaptic Plasticity and Network Repair Therapy in CBS/PSP

Circumventricular Organs

Age-Sensitive Cortical Vulnerability in Parkinson's Disease

MMP12 - Matrix Metallopeptidase 12

Synaptic Plasticity Therapeutics for Parkinson's Disease

ROBO1 Gene

BBB-Penetrant Antibody Engineering

RARB

IFIH1 Gene (MDA5)

Neurovascular Unit Dysfunction in Neurodegeneration

MMP14 (Matrix Metalloproteinase 14)

Vascular Leptomeningeal Cells