concept

NLGN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLGN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

222Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NLGN1 Gene
Summary	Page for NLGN1 Gene
Key Genes/Proteins	PSD95, neurexin, GluA1, Hevin, FN
Related Diseases	Alzheimer, Dementia
Related Pathways	Trans-Synaptic Adhesion Molecule Modulation

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NLGN1["NLGN1"]
    style NLGN1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    NLGN1 -->|"binds"| heparan_sulfate["heparan sulfate"]
    NLGN1 -->|"interacts"| PSD95([PSD95])
    NLGN1 -->|"participates in"| synapse["synapse"]
    NLGN1 -->|"interacts"| neurexin([neurexin])
    NLGN1 -->|"regulates"| GluA1([GluA1])
    NLGN1 -->|"regulates"| Trans_Synaptic_Adhesion_Molecu["Trans-Synaptic Adhesion Molecule Modulation"]
    NLGN1 -.->|"inhibits"| Alzheimer["Alzheimer"]
    NLGN1 -.->|"inhibits"| Dementia["Dementia"]
    NLGN1 -.->|"inhibits"| Als["Als"]
    h_fdaae8d9["h-fdaae8d9"] -->|"targets"| NLGN1
    Hevin([Hevin]) -->|"regulates"| NLGN1
    FN([FN]) -->|"regulates"| NLGN1
    NRXN2A([NRXN2A]) -->|"interacts"| NLGN1
    amyloid_beta_oligomers([amyloid-beta oligomers]) -->|"modulates"| NLGN1
    NRXN3([NRXN3]) -->|"interacts"| NLGN1
    EXOSOMES([EXOSOMES]) -.->|"inhibits"| NLGN1
    ALZHEIMER([ALZHEIMER]) -.->|"inhibits"| NLGN1
    NRXN2([NRXN2]) -->|"interacts"| NLGN1
    DEMENTIA([DEMENTIA]) -.->|"inhibits"| NLGN1

Outgoing (144)

Target	Relation	Type	Str
heparan sulfate	binds	chemical	0.90
PSD95	interacts_with	protein	0.80
neurexin	interacts_with	protein	0.80
GluA1	regulates	protein	0.80
neurons	expressed_in	cell_type	0.80
Trans-Synaptic Adhesion Molecule Modulation	regulates	mechanism	0.70
neurons	activates	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
Alzheimer	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Autism	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Autism	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
ALS	inhibits	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Autism	encodes	disease	0.65
Tau Propagation	regulates	biological_process	0.60
memory consolidation	involved_in	pathway	0.60
excitatory synapse	expressed_in	cell_type	0.60
excitatory synaptic transmission	involved_in	pathway	0.60
TSC2	activates	gene	0.60
TSC1	activates	gene	0.60
NLGN2	inhibits	gene	0.60
NLGN3	associated_with	gene	0.60
DCC	associated_with	gene	0.60
NRXN1	activates	gene	0.60
RORB	activates	gene	0.60
APP	activates	gene	0.60
NCAM2	activates	gene	0.60
GRIN2A	activates	gene	0.60
TSC2	encodes	gene	0.60
TSC1	encodes	gene	0.60
NRXN1	regulates	gene	0.60
NRXN3	regulates	gene	0.60
EPHA5	regulates	gene	0.60
MEF2C	regulates	gene	0.60
NPTX2	interacts_with	gene	0.60
RORA	activates	gene	0.60
Rb	activates	protein	0.60
Presenilin	regulates	protein	0.60
PSP	inhibits	gene	0.60
neurodegeneration	regulates	disease	0.60

Incoming (78)

Source	Relation	Type	Str
h-fdaae8d9	targets_gene	hypothesis	0.90
h-fdaae8d9	targets	hypothesis	0.80
Hevin	regulates	protein	0.80
FN	regulates	gene	0.70
NRXN2A	interacts_with	protein	0.60
amyloid-beta oligomers	modulates	protein	0.60
NRXN3	interacts_with	protein	0.60
NRXN2	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
NRXN1	activates	gene	0.60
RORB	activates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
NCAM2	activates	gene	0.60
RORA	activates	gene	0.60
FGF14	activates	gene	0.60
GRIN2A	activates	gene	0.60
NRXN1	regulates	gene	0.60
NRXN3	regulates	gene	0.60
NRXN2	regulates	gene	0.60
PSP	inhibits	gene	0.60
NGN1	regulates	gene	0.60
NGN2	regulates	gene	0.60
MEF2C	regulates	gene	0.60
EPHA5	regulates	gene	0.60
TSC1	activates	gene	0.60
TSC2	activates	gene	0.60
NLGN2	inhibits	gene	0.60
GEPHYRIN	interacts_with	gene	0.60
NRXN1	interacts_with	gene	0.60
NLGN3	associated_with	gene	0.60
DCC	associated_with	gene	0.60
ADNP	expressed_in	gene	0.60
EXOSOMES	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
SYNAPSE	inhibits	gene	0.60
SYNAPSE	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
AND	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AND	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Trans-Synaptic Adhesion Molecule Modulation	0.340	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (2)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
NRXN3-NLGN1 complex influences the development of depression induced by maternal [PMID:40286836]	Rong Y, Yan W, Gao Z, Yang Y, Xu C, Zhan	Brain research	2025
Membrane trafficking of synaptic adhesion molecules. [PMID:39322997]	["Bogaciu C", "Rizzoli S"]	The Journal of physiology	2025
Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation [PMID:41353490]	["Ji C", "Zhang Y", "Lin Z", "Zhao Z", "	Nature communications	2025
Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 [PMID:39574639]	Dharshini SAP, Sanz-Ros J, Pan J, Tang W	bioRxiv : the preprint server	2024
Cross-disorder and disease-specific pathways in dementia revealed by single-cell [PMID:39265576]	Rexach JE, Cheng Y, Chen L, Polioudakis	Cell	2024
Organizing the synaptic junctions. [PMID:37060998]	["Zhou Q"]	The Journal of biological chem	2023
A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and [PMID:37260747]	Arias-Aragón F, Tristán-Clavijo E, Martí	iScience	2023
Reelin through the years: From brain development to inflammation. [PMID:37339050]	Alexander A, Herz J, Calvier L	Cell reports	2023
Molecular mechanisms of synaptogenesis. [PMID:36176941]	["Qi C", "Luo L", "Feng I", "Ma S"]	Frontiers in synaptic neurosci	2022
In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse [PMID:36007521]	Nozawa K, Sogabe T, Hayashi A, Motohashi	Neuron	2022
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for [PMID:33522967]	Camporesi E, Lashley T, Gobom J, Lantero	Acta neuropathologica communic	2021
PSD-95 binding dynamically regulates NLGN1 trafficking and function. [PMID:31138690]	Jeong J, Pandey S, Li Y, Badger JD, Lu W	Proceedings of the National Ac	2019
NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and [PMID:29278843]	Katzman A, Alberini CM	Current opinion in neurobiolog	2018
Declining levels of functionally specialized synaptic proteins in plasma neurona [PMID:29025866]	Goetzl EJ, Abner EL, Jicha GA, Kapogiann	FASEB journal : official publi	2018
Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesi [PMID:28641111]	["Kim J", "Kim D", "Won S", "Han K", "Pa	Neuron	2017
Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid [PMID:26219651]	["Shen H", "Chen Z", "Wang Y", "Gao A",	Stroke	2015
Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphi [PMID:26674772]	Zhang Z, Yu H, Jiang S, Liao J, Lu T, Wa	PloS one	2015
Neurexins. [PMID:24083347]	["Reissner C", "Runkel F", "Missler M"]	Genome biology	2013
Genetic study of neurexin and neuroligin genes in Alzheimer's disease. [PMID:23403532]	Martinez-Mir A, González-Pérez A, Gayán	Journal of Alzheimer's disease	2013
Overexpression of the cell adhesion protein neuroligin-1 induces learning defici [PMID:19437420]	["Dahlhaus R", "Hines R", "Eadie B", "Ka	Hippocampus	2010

NLGN1

Understanding Entity Pages

Wiki Pages (21)

NLGN1 Gene

CNTN6 — Contactin 6

Epigenetic Dysregulation in Neurodegeneration

CNTN3 — Contactin 3

Allen Human Brain Atlas

TAR DNA-Binding Protein 43 (TDP-43)

Synaptogenesis in Neurodegeneration

mbnl1

Tau Immunotherapy

Tau Propagation Mechanisms

Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in Neurodegeneration

GRIN2A Protein

Tau Small-Molecule Therapeutics

NLGN3 Gene

ngn1

NTS — Neurotensin

RORB Gene

NEUROD2 Gene

Neuroligin 1 (NLGN1)

Synaptic Dysfunction in Neurodegeneration - SfN 2026 Research

NOVA1 — NOVA Alternative Splicing Regulator 1