Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP-43 INCLUSIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | causes | phenotype | 0.90 |
| ALS/FTD | associated_with | disease | 0.90 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.90 |
| Frontotemporal Lobar Degeneration | associated_with | disease | 0.90 |
| Alzheimer'S Disease | associated_with | disease | 0.80 |
| Proteostatic collapse | causes | mechanism | 0.70 |
| NEURONS | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 20948999 | co-localize with | paper | 0.90 |
| TDP-43 C-terminal fragmentation | causes | process | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-28 | 17 hypotheses Top: 0.828
neurodegeneration | 2025-12-31 | 23 hypotheses Top: 0.755
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.72 · 2026-04-28
closed · Rounds: 4 · Score: 0.75 · 2026-04-27
closed · Rounds: 4 · Score: 0.58 · 2026-04-27
closed · Rounds: 4 · Score: 0.77 · 2026-04-26
Hypotheses and analyses mentioning TDP-43 INCLUSIONS in their description or question text
No additional research found