Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALS/FTD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| polyunsaturated fatty acids (PUFAs) | protects_against | compound | 1.00 |
| C9ORF72 | risk_factor_for | gene | 0.95 |
| FBL | contributes_to | gene | 0.95 |
| VCP | risk_factor_for | gene | 0.90 |
| TDP-43 Dysfunction | contributes_to | mechanism | 0.90 |
| C9ORF72 | associated_with | gene | 0.90 |
| G4C2 Repeat Expansion | causes | biomarker | 0.90 |
| RNA Condensates | contributes_to | process | 0.85 |
| P53 | risk_factor_for | gene | 0.85 |
| Circadian Rhythm Disruption | associated_with | phenotype | 0.80 |
| C9ORF72 | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 | 0.601 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.606
neurodegeneration | 2026-04-06 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||