entity

TDP-43 inclusions

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43 inclusions: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

3Analyses

7Outgoing

2Incoming

0Experiments

5Debates

No AI portrait yet

Outgoing (7)

Target	Relation	Type	Str
Neurodegeneration	causes	phenotype	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Frontotemporal Lobar Degeneration	associated_with	disease	0.90
ALS/FTD	associated_with	disease	0.90
Alzheimer'S Disease	associated_with	disease	0.80
Proteostatic collapse	causes	mechanism	0.70
NEURONS	expressed_in	cell_type	0.55

Incoming (2)

Source	Relation	Type	Str
TDP-43 C-terminal fragmentation	causes	process	0.90
20948999	co-localize with	paper	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Cross-disease neurodegeneration mechanism synthesis

neurodegeneration | 2026-04-28 | 17 hypotheses Top: 0.828

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

neurodegeneration | 2026-04-07 | 3 hypotheses Top: 0.595

Test Hypothesis Fixtures

neurodegeneration | 2025-12-31 | 23 hypotheses Top: 0.755

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield

closed · Rounds: 4 · Score: 0.72 · 2026-04-28

Debate: TREM2 Microglial Activation Rescues Amyloid Clearance in AD

closed · Rounds: 4 · Score: 0.75 · 2026-04-27

Hypothesis debate: C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD

closed · Rounds: 4 · Score: 0.58 · 2026-04-27

Hypotheses created for system testing (hyp_test_* prefix)

closed · Rounds: 4 · Score: 0.77 · 2026-04-26

TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TDP-43 inclusions in their description or question text

No additional research found