protein

TDP1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Tyrosyl Dna Phosphodiesterase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	TDP1PROTEIN
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	** \| Nucleus, Cytoplasm \|
Molecular Weight	68 kDa
GeneCards	TDP1PROTEIN
Human Protein Atlas	TDP1PROTEIN
Domain architecture	TDP1 Family domain organization
Key motifs	DNA-binding domains, catalytic residues
Post-translational modifications	Phosphorylation, ubiquitination, SUMOylation
DNA repair	Essential for maintaining genomic integrity
Cell survival	Coordinates DNA damage response with cell survival
Neuronal function	Required for long-term neuronal survival
Genome stability	Prevents accumulation of mutations
Neurodegeneration	Impaired DNA repair leads to neuronal dysfunction
Associated Diseases	neurodegeneration
Interactions	App, CANCER, DNA, FEN1, HIF1A, NEURODEGENERATIVE DISEASES
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Tyrosyl-DNA Phosphodiesterase 1

protein · 570 words

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Pathway Diagram

graph TD
    TDP1PROTEIN["TDP1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TDP1PROTEIN -->|"implicated_in"| neurodegeneration
    style TDP1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TDP1PROTEIN in their description or question text

No additional research found