gene

FEN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FEN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

0Hypotheses

0Analyses

30Outgoing

16Incoming

0Experiments

0Debates

Summary

FEN1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, implicated in. Associated with ALS, Als, Cancer. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FEN1
Full Name	Flap Endonuclease 1
Chromosome	19q13.3
Function	FEN1 recognizes specific DNA structures through its DNA binding domain and coordinates cleavage at the flap-base junction 200345-8/fulltext).
Primary Expression	Hippocampus, Cerebral cortex, Cerebellum, Substantia nigra
Molecular Weight	43 kDa
UniProt ID	P39748
NCBI Gene ID	2237
Ensembl ID	ENSG00000163945
OMIM	600406
GeneCards	FEN1
Human Protein Atlas	FEN1
Interactions	AKT, AND, App, CANCER, DNA, NEURODEGENERATIVE DISEASES
KG Connections	46 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FEN1 — AlphaFold P39748 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FEN1["<b>FEN1</b>"]
    Cancer{"Cancer"}
    FEN1 -->|"activates"| Cancer
    Als{"Als"}
    FEN1 -->|"activates"| Als
    ALS{"ALS"}
    FEN1 -->|"activates"| ALS
    XPF["XPF"]
    FEN1 -->|"inhibits"| XPF
    XRCC1["XRCC1"]
    FEN1 -->|"activates"| XRCC1
    DNA["DNA"]
    FEN1 -->|"inhibits"| DNA
    SETX["SETX"]
    FEN1 -->|"activates"| SETX
    PNKP["PNKP"]
    FEN1 -->|"activates"| PNKP
    TDP1["TDP1"]
    FEN1 -->|"inhibits"| TDP1
    XPG["XPG"]
    FEN1 -->|"inhibits"| XPG
    CANCER["CANCER"]
    FEN1 -->|"activates"| CANCER
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    FEN1 -->|"activates"| NEURODEGENERATIVE_DISORDERS
    XPG -->|"inhibits"| FEN1
    SETX -->|"activates"| FEN1
    TDP1 -->|"inhibits"| FEN1
    PNKP -->|"activates"| FEN1
    XPF -->|"inhibits"| FEN1
    DNA -->|"inhibits"| FEN1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| FEN1
    AND["AND"]
    AND -->|"inhibits"| FEN1
    NEURODEGENERATIVE_DISORDERS -->|"activates"| FEN1
    XRCC1 -->|"activates"| FEN1
    style FEN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (30)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cancer	encodes	disease	0.65
Als	encodes	disease	0.65
Rb	inhibits	protein	0.60
Neuron	encodes	cell_type	0.60
PARP1	activates	gene	0.60
XPF	inhibits	gene	0.60
XRCC1	activates	gene	0.60
SETX	activates	gene	0.60
PNKP	activates	gene	0.60
TDP1	inhibits	gene	0.60
XPG	inhibits	gene	0.60
SETX	encodes	gene	0.60
cancer	regulates	disease	0.60
cancer	activates	disease	0.60
cancer	inhibits	disease	0.60
DNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
DNA	activates	gene	0.60
Neuron	activates	cell_type	0.60
CANCER	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (16)

Source	Relation	Type	Str
XPG	inhibits	gene	0.60
SETX	activates	gene	0.60
TDP1	inhibits	gene	0.60
PNKP	activates	gene	0.60
XPF	inhibits	gene	0.60
AKT	regulates	gene	0.60
AKT	activates	gene	0.60
AKT	inhibits	gene	0.60
XRCC1	activates	gene	0.60
PNKP	encodes	gene	0.60
XRCC1	encodes	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
CANCER	activates	gene	0.60
DNA	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
DNA	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity