concept

TIM-3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIM-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

1Hypotheses

1Analyses

16Outgoing

2Incoming

0Experiments

1Debates

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💡 Concept Info

Name	TIM-3
Key Genes/Proteins	HAVCR2, IL-6, INPP5D, TNF-α, TREM2
Related Diseases	Alzheimer's disease, Alzheimer's disease pathology
Related Pathways	FcγR, JAK/STAT3, NF-κB, PI3K-AKT

Pathway Diagram

graph TD
    TIM_3[TIM-3]
    TIM_3 -->|expressed in| Microglia[Microglia]
    TIM_3 -->|promotes| Neuroinflammation[Neuroinflammation]
    TIM_3 -->|inhibits| Amyloid_Clearance[Amyloid Clearance]
    TIM_3 -->|activates| JAK_STAT3[JAK/STAT3]
    TIM_3 -->|impairs| Fc_R[FcγR]
    TIM_3 -->|interacts| INPP5D[INPP5D]
    TIM_3 -->|interacts| TREM2[TREM2]
    TIM_3 -->|expressed in| microglia[microglia]
    TIM_3 -->|implicated in| Alzheimer_s_disease[Alzheimer's disease]
    TIM_3 -->|activates| TNF__[TNF-α]
    Tretinoin[Tretinoin] -->|targets| TIM_3
    HAVCR2[HAVCR2] -->|encodes| TIM_3

Outgoing (16)

Target	Relation	Type	Str
Microglia	expressed_in	cell_type	0.95
Neuroinflammation	promotes	process	0.90
Alzheimer's disease pathology	regulates	disease	0.90
Amyloid Clearance	inhibits	process	0.85
FcγR	impairs	pathway	0.80
INPP5D	interacts_with	gene	0.80
JAK/STAT3	activates	pathway	0.80
TREM2	interacts_with	gene	0.80
microglia	expressed_in	cell_type	0.80
Alzheimer's disease	implicated_in	disease	0.80
TNF-α	activates	protein	0.80
NF-κB	activates	pathway	0.80
IL-6	activates	protein	0.80
PI3K-AKT	impairs	pathway	0.80
microglia	regulates	cell_type	0.70
Alzheimer's disease	associated_with	disease	0.70

Incoming (2)

Source	Relation	Type	Str
Tretinoin	targets	drug	0.80
HAVCR2	encodes	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TIM-3 Checkpoint Modulation in Microglia	0.000	-	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 12 hypotheses Top: 0.726

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning TIM-3 in their description or question text

No additional research found