concept

PI3K-AKT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

1Hypotheses

1Analyses

23Outgoing

10Incoming

1Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PI3K-AKT
Key Genes/Proteins	AKT, GABARAPL1, GPR34, MAP1LC3
Related Diseases	Alzheimer's disease, ALZHEIMER'S DISEASE
Related Pathways	microglial_activation

Pathway Diagram

graph TD
    PI3K_AKT["PI3K-AKT"]
    PI3K_AKT -->|"activates"| MTOR["MTOR"]
    PI3K_AKT -->|"downregulates"| GABARAPL1["GABARAPL1"]
    PI3K_AKT -->|"mediates"| Cholesterol_Efflux["Cholesterol Efflux"]
    PI3K_AKT -->|"activates"| ZEB1["ZEB1"]
    PI3K_AKT -->|"activates"| SNAI1["SNAI1"]
    PI3K_AKT -->|"involved_in"| Cervical_Spondylotic_Myelopath["Cervical Spondylotic Myelopathy"]
    PI3K_AKT -->|"regulates"| apoptosis["apoptosis"]
    PI3K_AKT -->|"regulates"| cell_proliferation["cell proliferation"]
    P2RY12["P2RY12"] -->|"activates"| PI3K_AKT
    NTN1["NTN1"] -->|"activates"| PI3K_AKT
    NFE2L2["NFE2L2"] -->|"upstream_of"| PI3K_AKT
    ROS["ROS"] -->|"modulates"| PI3K_AKT
    ginsenosides["ginsenosides"] -->|"modulates"| PI3K_AKT
    natural_products["natural products"] -->|"activates"| PI3K_AKT

Outgoing (23)

Target	Relation	Type	Str
ALS	involved_in	disease	0.92
ALZHEIMER'S DISEASE	involved_in	disease	0.92
PARKINSON'S DISEASE	involved_in	disease	0.92
microglia activation	activates	process	0.90
GABARAPL1	downregulates	protein	0.90
MTOR	activates	entity	0.90
MICROGLIA	activates	cell_type	0.90
Cholesterol Efflux	mediates	process	0.85
MAP1LC3	regulates	protein	0.85
cholesterol efflux	associated_with	process	0.85
ALZHEIMER'S DISEASE	involved_in	disease	0.85
microglia activation	drives	process	0.85
ZEB1	activates	gene	0.85
SNAI1	activates	gene	0.85
Alzheimer's disease	implicated_in	disease	0.80
Cervical Spondylotic Myelopathy	involved_in	disease	0.75
microglial_activation	involved_in	mechanism	0.75
microglial survival	regulates	process	0.70
neurotoxicity	regulates	process	0.70
apoptosis	regulates	process	0.70
neuronal survival	activates	process	0.70
Parkinson's disease	associated_with	disease	0.70
cell proliferation	regulates	process	0.70

Incoming (10)

Source	Relation	Type	Str
P2RY12	activates	entity	0.90
NTN1	activates	entity	0.90
NFE2L2	upstream_of	gene	0.85
M1	activates	compound	0.80
TIM-3	impairs	protein	0.80
AKT	part_of	gene	0.80
GPR34	activates	gene	0.80
ginsenosides	modulates	drug	0.78
natural products	activates	drug	0.70
BP3	impacts	compound	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.718	alzheimers	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does SYK activation provide neuroprotection or exacerbate neuroinflammation in e

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	0.00	AD mouse hippocampus	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed fundamental uncertainty about whether enhancing TYROBP-SYK s

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning PI3K-AKT in their description or question text

No additional research found