PI3K-AKT

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    PI3K_AKT["PI3K-AKT"]
    PI3K_AKT -->|"activates"| MTOR["MTOR"]
    PI3K_AKT -->|"downregulates"| GABARAPL1["GABARAPL1"]
    PI3K_AKT -->|"mediates"| Cholesterol_Efflux["Cholesterol Efflux"]
    PI3K_AKT -->|"activates"| ZEB1["ZEB1"]
    PI3K_AKT -->|"activates"| SNAI1["SNAI1"]
    PI3K_AKT -->|"involved_in"| Cervical_Spondylotic_Myelopath["Cervical Spondylotic Myelopathy"]
    PI3K_AKT -->|"regulates"| apoptosis["apoptosis"]
    PI3K_AKT -->|"regulates"| cell_proliferation["cell proliferation"]
    P2RY12["P2RY12"] -->|"activates"| PI3K_AKT
    NTN1["NTN1"] -->|"activates"| PI3K_AKT
    NFE2L2["NFE2L2"] -->|"upstream_of"| PI3K_AKT
    ROS["ROS"] -->|"modulates"| PI3K_AKT
    ginsenosides["ginsenosides"] -->|"modulates"| PI3K_AKT
    natural_products["natural products"] -->|"activates"| PI3K_AKT