gene

TMBIM6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMBIM6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

3Outgoing

4Incoming

Summary

TMBIM6 (BAX Inhibitor 1/BI1) - ER membrane protein with anti-apoptotic and neuroprotective functions in neurodegeneration

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🧬 Gene Info

Gene Symbol	TMBIM6
Full Name	Transmembrane BAX Inhibitor Motif Containing 6 (BAX Inhibitor 1)
Aliases	BAX Inhibitor 1/BI1
Chromosome	12q13.12
Function	is a highly conserved anti-apoptotic protein localized primarily to the endoplasmic reticulum (ER) membrane.
Molecular Weight	33 kDa
Amino Acids	299 aa
Pathways	Pyroptosis
Ensembl ID	ENSG00000125148
GeneCards	TMBIM6
Human Protein Atlas	TMBIM6
Associated Diseases	neurodegeneration
Interactions	BAX, PIEZO1, PYROPTOSIS, GENES
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    TMBIM6(["TMBIM6"])
    Cancer["Cancer"]
    Cardiac["Cardiac"]
    Pyroptosis["Pyroptosis"]
    BAX(["BAX"])
    PYROPTOSIS(["PYROPTOSIS"])
    PIEZO1(["PIEZO1"])
    GENES(["GENES"])
    neurodegeneration["neurodegeneration"]

    TMBIM6 -->|"therapeutic target"| Cancer
    TMBIM6 -->|"activates"| Cardiac
    TMBIM6 -->|"activates"| Pyroptosis
    BAX -->|"activates"| TMBIM6
    PYROPTOSIS -->|"activates"| TMBIM6
    PIEZO1 -->|"activates"| TMBIM6
    GENES -->|"activates"| TMBIM6
    TMBIM6 -->|"implicated in"| neurodegeneration

    style TMBIM6 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.65
Cardiac	activates	disease	0.65
Pyroptosis	activates	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
BAX	activates	gene	0.60
PIEZO1	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found