BAX

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

BAX is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 1233 entities in the SciDEX knowledge graph.

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graph TD
    BAX["<b>BAX</b><br/>(Pro-apoptotic Protein)""]
    
    subgraph Regulators["Regulatory Inputs"]
        LRWE["LRWE<br/>(Regulator)"]
        gallic["Gallic Acid<br/>(Compound)"]
        cadmium["Cadmium<br/>(Heavy Metal)"]
        magnolol["Magnolol<br/>(Compound)"]
        tirzepatide["Tirzepatide<br/>(Drug)"]
    end
    
    subgraph CorePathways["Core Molecular Functions"]
        apoptosis["Apoptosis<br/>(Cell Death)"]
        bcl2["BCL2<br/>(Anti-apoptotic Protein)"]
    end
    
    subgraph DiseaseProtection["Disease Protection/Inhibition"]
        cancer["Cancer"]
        als["ALS<br/>(Amyotrophic Lateral Sclerosis)"]
        aging["Aging"]
        hf["Heart Failure"]
        inflammation["Inflammation"]
        hepatitis["Hepatitis"]
        fibrosis["Fibrosis"]
    end
    
    subgraph DiseaseAssociation["Disease Association/Activation"]
        lymphoma["Lymphoma"]
        ms["Multiple Sclerosis"]
    end
    
    LRWE -->|"regulates<br/>0.8"| BAX
    gallic -->|"associated_with<br/>0.9"| BAX
    cadmium -->|"inhibits<br/>0.7"| BAX
    magnolol -->|"inhibits<br/>0.7"| BAX
    tirzepatide -->|"inhibits<br/>0.7"| BAX
    
    BAX -->|"activates<br/>0.9"| apoptosis
    BAX -->|"interacts_with<br/>0.7"| bcl2
    
    BAX -->|"inhibits<br/>0.65"| cancer
    BAX -->|"inhibits<br/>0.65"| als
    BAX -->|"inhibits<br/>0.65"| aging
    BAX -->|"inhibits<br/>0.65"| hf
    BAX -->|"inhibits<br/>0.65"| inflammation
    BAX -->|"inhibits<br/>0.65"| hepatitis
    BAX -->|"inhibits<br/>0.65"| fibrosis
    
    BAX -->|"associated_with<br/>0.65"| lymphoma
    BAX -->|"associated_with<br/>0.65"| ms
    
    classDef mainGene fill:#ff6b6b,stroke:#c92a2a,stroke-width:3px,color:#e0e0e0
    classDef protein fill:#4ecdc4,stroke:#0a9396,stroke-width:2px,color:#e0e0e0
    classDef compound fill:#95e1d3,stroke:#38ada9,stroke-width:2px,color:#e0e0e0
    classDef process fill:#ffd93d,stroke:#ffb703,stroke-width:2px,color:#e0e0e0
    classDef disease fill:#a8e6cf,stroke:#56ab91,stroke-width:2px,color:#e0e0e0
    classDef diseaseNeg fill:#ff8b94,stroke:#d62828,stroke-width:2px,color:#e0e0e0
    
    class BAX mainGene
    class bcl2,LRWE protein
    class gallic,cadmium,magnolol,tirzepatide compound
    class apoptosis process
    class cancer,als,aging,hf,inflammation,hepatitis,fibrosis disease
    class lymphoma,ms diseaseNeg