SciDEX — TOM

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Target	Relation	Type	Str
PINK1	binds	protein	0.90
PINK1 retention	promotes	phenotype	0.85

Source	Relation	Type	Str
No incoming edges

Hypothesis	Score	Disease	Analysis
Spatial Transcriptome-Guided Precision Cell Therapy	0.412	neurodegeneration	Cell type vulnerability in Alzheimer's D

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

neurodegeneration | 2026-04-11 | 0 hypotheses

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

systems biology | 2026-04-11 | 0 hypotheses

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

neurodegeneration | 2026-04-10 | 0 hypotheses

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

How do protein-protein interactions determine subcellular localization and funct

synaptic biology | 2026-04-08 | 0 hypotheses

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

neurodegeneration | 2026-04-08 | 0 hypotheses

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Trans-synaptic tau spreading and propagation mechanisms in AD

neuroscience | 2026-04-04 | 0 hypotheses

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Human connectome alterations and network-level dysfunction in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.462

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.502

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-02 | 0 hypotheses

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-02 | 0 hypotheses

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-02 | 0 hypotheses

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

neurodegeneration | 2026-04-02 | 0 hypotheses

TOM

Understanding Entity Pages

Wiki Pages (20)

Mitochondrial Quality Control

Mitophagy Pathway in Neurodegeneration

mitophagy-defect

YME1L1 Gene

pink1-parkin-mitophagy-pd-causal-chain

Outgoing (2)

Incoming (0)

Targeting Hypotheses (1)

Mentioning Analyses (24)

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

What molecular mechanisms drive the transition from acute to persistent neuroinf

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

What is the atomic-resolution structure of K280-acetylated tau and how does it t

How can functional hyperconnectivity patterns distinguish compensatory mechanism

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

What are the specific molecular mechanisms by which C1Q components drive atheros

Trans-synaptic tau spreading and propagation mechanisms in AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Human connectome alterations and network-level dysfunction in Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Related Papers (0)

TOM

Understanding Entity Pages

Wiki Pages (20)

Mitochondrial Quality Control

Mitophagy Pathway in Neurodegeneration

mitophagy-defect

YME1L1 Gene

pink1-parkin-mitophagy-pd-causal-chain

TFAM Gene

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

grp75-calcium-homeostasis-parkinsons

SCO1 — Cytochrome c Oxidase Assembly Factor SCO1

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

NMNAT3 — Nicotinamide Mononucleotide Adenylyltransferase 3

Huntingtin-Mitochondrial Dysfunction in Huntington's Disease

exenatide-parkinsons

Mitophagy

timm17a

Mitochondrially Impaired Neurons

LARS2 — Leucyl-tRNA Synthetase 2, Mitochondrial

VCP→TDP-43→ALS/FTD Causal Chain

Mitochondrial Dysfunction Pathway in Neurodegeneration

Cure Parkinson's

Outgoing (2)

Incoming (0)

Targeting Hypotheses (1)

Mentioning Analyses (24)

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

What molecular mechanisms drive the transition from acute to persistent neuroinf

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

What is the atomic-resolution structure of K280-acetylated tau and how does it t

How can functional hyperconnectivity patterns distinguish compensatory mechanism

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

What are the specific molecular mechanisms by which C1Q components drive atheros

Trans-synaptic tau spreading and propagation mechanisms in AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Human connectome alterations and network-level dysfunction in Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Related Papers (0)