gene 720 words KG: TOMM40 2026-03-24
kind:genesection:genesstate:published
Contents

TOMM40 Gene

🧬 Gene Info
Gene SymbolTOMM40
Full NameTranslocase of Outer Mitochondrial Membrane 40
Chromosome19q13.32
FunctionTOMM40 is the core component of the TOM complex, the primary gateway for protein import into mitochondria.
Molecular Weight38 kDa
PathwaysMitophagy
UniProt IDQ9NTU5
NCBI Gene ID219988
Ensembl IDENSG00000130254
OMIM608633
GeneCardsTOMM40
Human Protein AtlasTOMM40
ApproachStatus
Mitochondrial Biogenesis InducersResearch
Gene TherapyPreclinical
Associated DiseasesAging, Alzheimer
InteractionsNME8, PTK2B, MS4A6A, PICALM, ABCA7, CR1
KG Connections90 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with
MAP1LC3B — LC3B
gene · KG edge: regulates
MAP1LC3A Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

TOMM40 regulates ATG12
TOMM40 regulates ULK1
TOMM40 inhibits TUFM
TOMM40 interacts_with NME8
TOMM40 interacts_with PTK2B
TOMM40 interacts_with MS4A6A
TOMM40 interacts_with PICALM
TOMM40 interacts_with CD2AP
TOMM40 interacts_with ABCA7
TOMM40 interacts_with CR1