TDP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TDP1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with ALS, Als, Cancer. Connected to 33 entities in the SciDEX knowledge graph.

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graph TD
    TDP1["<b>TDP1</b>"]
    Cancer{"Cancer"}
    TDP1 -->|"activates"| Cancer
    Als{"Als"}
    TDP1 -->|"activates"| Als
    TDP1 -->|"therapeutic target"| Cancer
    TDP1 -->|"therapeutic target"| Als
    ALS{"ALS"}
    TDP1 -->|"activates"| ALS
    PNKP["PNKP"]
    TDP1 -->|"activates"| PNKP
    FEN1["FEN1"]
    TDP1 -->|"inhibits"| FEN1
    XPF["XPF"]
    TDP1 -->|"inhibits"| XPF
    XRCC1["XRCC1"]
    TDP1 -->|"activates"| XRCC1
    DNA["DNA"]
    TDP1 -->|"inhibits"| DNA
    SETX["SETX"]
    TDP1 -->|"activates"| SETX
    MAPK1["MAPK1"]
    TDP1 -->|"therapeutic target"| MAPK1
    XPG["XPG"]
    XPG -->|"inhibits"| TDP1
    SETX -->|"activates"| TDP1
    XPF -->|"inhibits"| TDP1
    PNKP -->|"activates"| TDP1
    NFKB1["NFKB1"]
    NFKB1 -->|"therapeutic target"| TDP1
    ERK["ERK"]
    ERK -->|"therapeutic target"| TDP1
    TRIM24["TRIM24"]
    TRIM24 -->|"therapeutic target"| TDP1
    FEN1 -->|"inhibits"| TDP1
    DNA -->|"inhibits"| TDP1
    AND["AND"]
    AND -->|"activates"| TDP1
    style TDP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0