PNKP

Understanding Entity Pages

This page aggregates everything SciDEX knows about PNKP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DNA repair enzyme with dual kinase/phosphatase activity essential for neuronal genomic integrity and linked to ataxia and Parkinson's disease

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graph TD
    PNKP["<b>PNKP</b>"]
    Cancer{"Cancer"}
    PNKP -->|"activates"| Cancer
    Als{"Als"}
    PNKP -->|"activates"| Als
    ALS{"ALS"}
    PNKP -->|"activates"| ALS
    FEN1["FEN1"]
    PNKP -->|"activates"| FEN1
    XPF["XPF"]
    PNKP -->|"activates"| XPF
    XRCC1["XRCC1"]
    PNKP -->|"activates"| XRCC1
    XPG["XPG"]
    PNKP -->|"activates"| XPG
    TDP1["TDP1"]
    PNKP -->|"activates"| TDP1
    DNA["DNA"]
    PNKP -->|"activates"| DNA
    SETX["SETX"]
    PNKP -->|"activates"| SETX
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    PNKP -->|"activates"| NEURODEGENERATIVE_DISEASES
    CANCER["CANCER"]
    PNKP -->|"activates"| CANCER
    XPG -->|"activates"| PNKP
    SETX -->|"activates"| PNKP
    TDP1 -->|"activates"| PNKP
    XPF -->|"activates"| PNKP
    FEN1 -->|"activates"| PNKP
    style PNKP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0