Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Trazodone: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Slow-wave sleep continuity | enhances | process | 0.90 |
| 5-HT2A receptor | inhibits | protein | 0.90 |
| Sigma-1 receptor | activates | protein | 0.70 |
| REM sleep duration | enhances | process | 0.70 |
| BDNF serum levels | increases | biomarker | 0.70 |
| NEURODEGENERATION | inhibits | disease | 0.65 |
| NEURODEGENERATION | protects_against | disease | 0.65 |
| DEMENTIA | associated_with | disease | 0.45 |
| TAU | associated_with | protein | 0.45 |
| SEROTONIN | associated_with | phenotype | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 25719754 | reduces | paper | 0.90 |
| 25719754 | does not worsen | paper | 0.90 |
| 25719754 | was not associated with significant change in | paper | 0.60 |
| 25719754 | could be effective therapy for | paper | 0.60 |
| NEURODEGENERATION | associated_with | disease | 0.45 |
| PRION DISEASE | associated_with | disease | 0.45 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| DEPRESSION | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Sigma-1 Receptor-Mediated UPR Reset as Primary Disease-Modif | 0.605 | - | What is the minimum effective dose of tr |
| Direct ISR target engagement likely requires trazodone doses | 0.590 | neurodegeneration | - |
| A lower trazodone dose of 50-100 mg nightly may be sufficien | 0.580 | neurodegeneration | - |
| High baseline tau and ISR activation may lower the effective | 0.510 | neurodegeneration | - |
| Patients with OSA or high nocturnal arousal burden may requi | 0.370 | neurodegeneration | - |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.605
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Trazodone in their description or question text
No additional research found