gene

DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7021Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

DEMENTIA is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALS, ALZHEIMER. Connected to 1765 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	DEMENTIA
Full Name	Cortical Neurons in Frontotemporal Dementia
Protein Type	Cell Type
Associated Diseases	ALS, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, Aging, Alzheimer
Known Drugs/Compounds	SEMAGLUTIDE, LECANEMAB, MEMANTINE, RAPAMYCIN, EMPAGLIFLOZIN, Quercetin
Interactions	AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY, LMNA, CNO, APOE, TAU
KG Connections	4214 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Dementia["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Aging["Aging"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Alzheimer_1["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Alzheimer_2["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Dementia_3["Dementia"]
        APP["APP"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE_6["ALZHEIMER'S DISEASE"] -->|"causes"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_7["ALZHEIMER"] -->|"causes"| DEMENTIA["DEMENTIA"]
    end
    subgraph Signaling["Signaling"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Alzheimer["Alzheimer"]
        DEMENTIA["DEMENTIA"] -.->|"inhibits"| Dementia_4["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Dementia_5["Dementia"]
    end
    subgraph Interactions["Interactions"]
        ALS["ALS"] -->|"interacts with"| DEMENTIA["DEMENTIA"]
    end
    style DEMENTIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_5 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE_6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3095)

Target	Relation	Type	Str
Dementia	associated_with	disease	1.00
Alzheimer	activates	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Aging	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
Alzheimer	causes	disease	1.00
Dementia	causes	disease	1.00
Dementia	inhibits	disease	1.00
Dementia	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Parkinson	associated_with	disease	1.00
Neuroinflammation	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Aging	activates	disease	1.00
Amyotrophic Lateral Sclerosis	causes	disease	1.00
Parkinson	causes	disease	1.00
Neurodegeneration	biomarker_for	disease	1.00
Dementia	regulates	disease	1.00
Dementia	contributes_to	disease	1.00
Neurodegeneration	causes	disease	1.00
Inflammation	regulates	disease	1.00
Dementia	biomarker_for	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
Alzheimer	therapeutic_target	disease	1.00
Dementia	therapeutic_target	disease	1.00
ALZHEIMER	therapeutic_target	gene	1.00
AMYLOID	therapeutic_target	gene	1.00
Als	associated_with	disease	1.00
ALZHEIMER	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
ALZHEIMER	contributes_to	gene	1.00
Alzheimer	contributes_to	disease	1.00
MICROGLIA	activates	cell_type	1.00
Als	causes	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
Neuroinflammation	activates	disease	1.00
Als	implicated_in	disease	1.00
Alzheimer	implicated_in	disease	1.00
Dementia	implicated_in	disease	1.00
Als	treats	disease	1.00
Dementia	treats	disease	1.00
ALZHEIMER	causes	gene	1.00

Incoming (3926)

Source	Relation	Type	Str
APP	associated_with	gene	1.00
ALS	interacts_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
ALZHEIMER'S DISEASE	causes	gene	1.00
ALZHEIMER	causes	gene	1.00
ALS	activates	gene	1.00
AMYLOID	associated_with	gene	1.00
ALS	associated_with	gene	1.00
ALS	causes	gene	1.00
GENES	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
PARKINSON	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	1.00
NEURODEGENERATION	biomarker_for	gene	1.00
INFLAMMATION	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
TAU	therapeutic_target	gene	1.00
TAU	associated_with	gene	1.00
ALZHEIMER	implicated_in	gene	1.00
TAU	biomarker_for	gene	1.00
ALZHEIMER	biomarker_for	gene	1.00
AMYLOID	biomarker_for	gene	1.00
APOPTOSIS	associated_with	gene	1.00
APOE	associated_with	gene	1.00
MAPT	associated_with	gene	1.00
TNF	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
SOD1	associated_with	gene	1.00
TARDBP	associated_with	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
ALZHEIMER	activates	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
PARKINSON	causes	gene	1.00
C9ORF72	causes	gene	1.00
AGING	associated_with	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	biomarker_for	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
FUS	associated_with	gene	0.98
NF-KB	associated_with	protein	0.98
Cardiovascular Disease	risk_factor_for	disease	0.95
Inflammasome	contributes_to	pathway	0.92
TAU	causes	gene	0.90
ALZHEIMER'S DISEASE	regulates	gene	0.90
AKT	associated_with	gene	0.90
Microbiota-Gut-Brain Axis	associated_with	pathway	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DEMENTIA

Understanding Entity Pages

Summary

Wiki Pages (21)

Cortical Neurons in Frontotemporal Dementia

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

Atypical Parkinsonism

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence