concept

HIPPOCAMPUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIPPOCAMPUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1883Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HIPPOCAMPUS is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, causes. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 84 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIPPOCAMPUS
Summary	Anatomical structure, function, and disease relevance in neurodegeneration
Key Genes/Proteins	NF-KB, SLC17A7, APP
Related Diseases	ALZHEIMER'S DISEASE, DEPRESSION
Linked Hypotheses	4 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Parkinson's Disease

disease · 8807 words

→

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

→

Pathway Diagram

graph TD
    HIPPOCAMPUS["HIPPOCAMPUS"]
    HIPPOCAMPUS -->|"activates"| Memory["Memory"]
    HIPPOCAMPUS -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    BDNF["BDNF"] -->|"expressed in"| HIPPOCAMPUS
    BMSC_exos["BMSC-exos"] -->|"expressed in"| HIPPOCAMPUS
    SNCA["SNCA"] -->|"expressed in"| HIPPOCAMPUS
    mitophagy["mitophagy"] -->|"expressed in"| HIPPOCAMPUS
    blood_brain_barrier["blood-brain barrier"] -->|"regulates"| HIPPOCAMPUS
    neurogenesis["neurogenesis"] -->|"expressed in"| HIPPOCAMPUS
    SMAD7["SMAD7"] -->|"expressed in"| HIPPOCAMPUS
    autophagy["autophagy"] -->|"expressed in"| HIPPOCAMPUS
    GFAP["GFAP"] -->|"expressed in"| HIPPOCAMPUS
    senescent_microglia["senescent microglia"] -->|"expressed in"| HIPPOCAMPUS

Outgoing (570)

Target	Relation	Type	Str
NEURON	activates	cell_type	0.95
MICROGLIA	regulates	cell_type	0.95
NEUROGENESIS	regulates	process	0.95
NEURON	regulates	cell_type	0.95
NEURON	protects_against	cell_type	0.95
NEUROGENESIS	associated_with	process	0.95
NEURODEGENERATION	causes	process	0.80
MICROGLIA	inhibits	cell_type	0.80
NEURON	interacts_with	cell_type	0.80
NEUROINFLAMMATION	inhibits	process	0.80
NEURON	therapeutic_target	cell_type	0.80
TAU	activates	protein	0.80
AKT	stabilizes	gene	0.70
PARKINSON	stabilizes	disease	0.70
PARKINSON	treats	disease	0.70
AMYLOID	protects_against	protein	0.70
NEUROGENESIS	treats	phenotype	0.70
MAPT	activates	gene	0.65
NEURODEGENERATION	activates	disease	0.65
PSEN2	activates	gene	0.65
SQSTM1	expressed_in	gene	0.65
MICROGLIA	expressed_in	cell_type	0.65
IL-6	activates	gene	0.65
STAT3	activates	gene	0.65
STING	activates	gene	0.65
IL6	activates	gene	0.65
IL-6	contributes_to	gene	0.65
NRF2	inhibits	gene	0.65
LOCUS COERULEUS	exacerbates	brain_region	0.65
MTOR	activates	gene	0.65
PSD95	increases	gene	0.65
MICROGLIA	activates	cell_type	0.65
PREFRONTAL	contributes_to	brain_region	0.65
INTERNEURONS	expressed_in	cell_type	0.65
TAU	inhibits	protein	0.65
PI3K	activates	gene	0.65
NEUROINFLAMMATION	activates	process	0.65
OXIDATIVE STRESS	inhibits	process	0.65
NEURON	biomarker_for	cell_type	0.65
STRIATUM	expressed_in	brain_region	0.65
PREFRONTAL CORTEX	contributes_to	brain_region	0.65
MICROGLIA	phosphorylates	cell_type	0.65
NLRP3	phosphorylates	gene	0.65
WNT	phosphorylates	gene	0.65
TAU	targets	gene	0.65
PSEN2	regulates	gene	0.65
ENDOTHELIAL CELLS	treats	cell_type	0.65
GLUTAMATE	causes	phenotype	0.65
CYTOKINES	regulates	phenotype	0.65
ASTROCYTE	causes	cell_type	0.65

Incoming (1313)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
MICROGLIA	activates	cell_type	1.00
NF-KB	associated_with	protein	1.00
TAU	associated_with	protein	1.00
MICROGLIA	associated_with	cell_type	1.00
BDNF	associated_with	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
APP	associated_with	gene	1.00
SLC17A7	enriched_in	gene	0.95
CORTEX	regulates	brain_region	0.95
DEPRESSION	activates	disease	0.95
CORTEX	activates	brain_region	0.95
ALZHEIMER'S DISEASE	interacts_with	disease	0.95
APP	expressed_in	gene	0.95
CORTEX	inhibits	brain_region	0.95
BDNF	inhibits	gene	0.90
IL-6	associated_with	gene	0.90
HCN1	expressed_in	entity	0.90
SPP1	expressed_in	entity	0.90
C1Q	expressed_in	entity	0.85
MICROGLIA	expressed_in	entity	0.85
TDP43	expressed_in	entity	0.85
C4B	upregulated_in	gene	0.85
APOE	associated_with	gene	0.82
AMYLOID	activates	protein	0.82
AKT	associated_with	gene	0.82
APP	inhibits	gene	0.82
AUTOPHAGY	associated_with	process	0.82
RELN	expressed_in	entity	0.80
ALZHEIMER'S DISEASE	protects_against	disease	0.80
AMYGDALA	expressed_in	brain_region	0.80
CEREBRAL CORTEX	activates	brain_region	0.80
TNF	associated_with	gene	0.80
SELENOPROTEIN P	transports	protein	0.80
LRP8	binds_to	protein	0.80
BAX	associated_with	gene	0.74
PI3K	associated_with	gene	0.74
PARKINSON'S DISEASE	associated_with	disease	0.72
MICROGLIA	inhibits	cell_type	0.72
CASP3	associated_with	gene	0.72
AQP4	phosphorylates	gene	0.70
AQP4	causes	gene	0.70
AQP4	activates	gene	0.70
QUERCETIN	activates	drug	0.70
APP	produces	gene	0.70
CYP46A1	causes	gene	0.70
CYP46A1	exacerbates	gene	0.70
VCP	phosphorylates	gene	0.70
VCP	causes	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HIPPOCAMPUS

Understanding Entity Pages

Summary

Wiki Pages (21)

Hippocampus

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Parthanatos in Neurodegeneration

Alpha-Synuclein Pathology

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

NPM1 Gene

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison