gene

UGDH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UGDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

UGDH: UDP-Glucose 6-Dehydrogenase - enzyme crucial for glycosaminoglycan biosynthesis, heparan sulfate metabolism, and neurodegenerative disease pathways

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🧬 Gene Info

Gene Symbol	UGDH
Full Name	UDP-Glucose 6-Dehydrogenase
Aliases	UGDH: UDP-Glucose 6-Dehydrogenase
Chromosome	4p15.1
Protein Type	Enzyme
Function	is a crucial NAD-dependent enzyme that catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid, a key precursor for glycosaminoglycan (GAG) biosynthesis[@barash1999][@wang2000].
Primary Expression	both neurons and glia, where it contributes to the maintenance of extracellular matrix integrity, neuroinflammation regulation, and cellular stress re
Molecular Weight	52 kDa
Amino Acids	463 aa
Exons	11
UniProt ID	[Q9Y2K2](https://www.uniprot.org/uniprot/Q9Y2K2)
Ensembl ID	ENSG00000108639
GeneCards	UGDH
Human Protein Atlas	UGDH
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

UGDH — UDP-Glucose 6-Dehydrogenase

gene · 2281 words

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UDP-Glucose 6-Dehydrogenase (UGDH) Protein

protein · 2134 words

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Pathway Diagram

graph TD
    UGDH["UGDH"]
    neurodegeneration["neurodegeneration"]
    UGDH -->|"implicated_in"| neurodegeneration
    style UGDH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UGDH in their description or question text

No additional research found