Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about White Matter Degeneration: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
White matter degeneration is a critical pathological feature of numerous neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, vascular dementia, and multiple sclerosis. White matter consists of myelinated axons that enable rapid communication between different brain region
| Name | White Matter Degeneration |
| Summary | Page for White Matter Degeneration |
| Linked Hypotheses | 3 hypotheses |
Knowledge base pages for this entity
flowchart LR
N554["White Matter-Associated Microglia"] -->|"protects_against"| N21["White Matter Degeneration"]
N3431["Aging"] -->|"causes"| N21["White Matter Degeneration"]
N2638["Microglia"] -->|"associated_with"| N21["White Matter Degeneration"]
N5844["Ferroptosis"] -->|"mediates"| N21["White Matter Degeneration"]
style N554 fill:#adb5bd,color:#e0e0e0
style N21 fill:#ef5350,color:#fff
style N3431 fill:#adb5bd,color:#e0e0e0
style N2638 fill:#adb5bd,color:#e0e0e0
style N5844 fill:#adb5bd,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Aging | causes | process | 0.90 |
| Microglia | associated_with | cell_type | 0.90 |
| White Matter-Associated Microglia | protects_against | cell_type | 0.85 |
| Ferroptosis | mediates | process | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive | 0.512 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| OPC differentiation blockade contributes to white matter deg | 0.495 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
| ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo | 0.493 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. [PMID:41819088] | Liu L, Zheng Z, You W, Yang P, Wen Y et | Cell Metab | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Vitamin C slows primate aging by targeting iron-driven lipid peroxidation. [PMID:41950897] | Yu PL, Xu CR | Cell Metab | 2026 | 0 |
| The IL-33/ST2 Signaling Axis Alleviates Splenic Injury in Severe Acute Pancreati [PMID:41954769] | Cui L, Xu N, Chen J, Bin C, Feng Y et al | Pancreas | 2026 | 0 |
| Fibroblast-Specific GPX4 Deletion Exacerbates IBD via Lipid Peroxidation. [PMID:41955120] | Zhang Y, Ying Y, Huang W, Rosenfeld ZA, | Am J Physiol Gastrointest Live | 2026 | 0 |
| Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] | Li C, Teng T, Lin X, Sun X, Yi T et al. | Cancer Res | 2026 | 0 |
| A cellular epigenetic classification system for glioblastoma. [PMID:41499453] | Silverbush D, Jürgensen L, Freeburg NF, | Neuro Oncol | 2026 | 0 |
| Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] | Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan | J Gastroenterol Hepatol | 2026 | 0 |
| P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] | Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. | Circulation | 2026 | 0 |
| Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] | Ye D, Zhou H, Qu S, Wang Z, Zhang F et a | Cell Death Discov | 2026 | 0 |
| Comparison of gene fusion detection algorithms reveals frequently overlooked dri [PMID:41935182] | Tamura Z, Saito Y, Kogure Y, Oshikawa-Ku | NPJ Precis Oncol | 2026 | 0 |
| Single-cell transcriptome analysis indicated that immune-related programmed cell [PMID:41946148] | Sun J, Jing L, Zhu X, Yang H, Sun Y et a | Transl Oncol | 2026 | 0 |
| Lipid emulsion modulates myogenic and collagen-related gene expression in skelet [PMID:41955312] | Li X, Alaniz SM, Louey S, Deavila JM, Jo | Exp Physiol | 2026 | 0 |