gene

abhd12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about abhd12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

5Outgoing

1Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ABHD12
Full Name	Alpha/Beta Hydrolase Domain Containing 12
Chromosome	20p11.21
Protein Type	Hydrolase
Function	encodes a brain-enriched serine hydrolase enzyme that plays critical roles in lipid metabolism, endocannabinoid signaling, and neuroimmune function.
Primary Expression	the central nervous system, particularly in neurons, microglia, and oligodendrocytes, where it hydrolyzes various lipid substrates including monoacylg
Exons	14
UniProt ID	Q9NWU1
NCBI Gene ID	553155
Ensembl ID	ENSG00000153048
OMIM	613599
GeneCards	ABHD12
Human Protein Atlas	ABHD12
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: abhd12 — AlphaFold Q9NWU1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    N0["ABHD12"]
    N1["HOS1"]
    N0 -->|"interacts with"| N1
    N2["ICE1"]
    N0 -->|"phosphorylates"| N2
    N3["Freezing Tolerance"]
    N0 -->|"associated with"| N3
    N4["BRCA1"]
    N0 -->|"interacts with"| N4
    N5["CBF Pathway"]
    N0 -->|"participates in"| N5
    N6["neurodegeneration"]
    N0 -->|"implicated in"| N6

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N4 gene
    class N5 pathway

Outgoing (5)

Target	Relation	Type	Str
HOS1	interacts_with	enzyme	0.80
Freezing Tolerance	associated_with	phenotype	0.80
BRCA1	interacts_with	gene	0.70
CBF Pathway	participates_in	pathway	0.70
benchmark_ot_ad_answer_key:ABHD12	data_in	dataset_row	0.00

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABHD12	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

abhd12

Understanding Entity Pages

Wiki Pages (7)

Endocannabinoid System Dysfunction Hypothesis in Parkinson's Disease

Endocannabinoid System in Neurodegeneration

ABHD12 Gene

Genes Overview

ABHD12 Protein - Alpha/Beta Hydrolase Domain Containing 12