concept

AMYLOID-BETA PLAQUES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID-BETA PLAQUES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

1Analyses

4Outgoing

15Incoming

0Experiments

1Debates

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💡 Concept Info

Name	AMYLOID-BETA PLAQUES

Pathway Diagram

graph TD
    AMYLOID_BETA_PLAQUES[AMYLOID-BETA PLAQUES]
    AMYLOID_BETA_PLAQUES -.biomarker for.-> Alzheimer_S_Disease[Alzheimer'S Disease]
    AMYLOID_BETA_PLAQUES -.biomarker for.-> Alzheimer_s_Disease[Alzheimer's Disease]
    AMYLOID_BETA_PLAQUES -->|causes| Excitatory_Synapse_Loss[Excitatory Synapse Loss]
    Apoe4[Apoe4] -->|promotes| AMYLOID_BETA_PLAQUES
    Digestive_Exophagy[Digestive Exophagy] -->|mediates| AMYLOID_BETA_PLAQUES
    APP_MUTATION[APP MUTATION] -->|causes| AMYLOID_BETA_PLAQUES
    BIN1[BIN1] -->|involved_in| AMYLOID_BETA_PLAQUES
    CGAS[CGAS] -->|expressed in| AMYLOID_BETA_PLAQUES
    STING[STING] -->|expressed in| AMYLOID_BETA_PLAQUES
    acid_phosphatase[acid phosphatase] -->|regulates| AMYLOID_BETA_PLAQUES

Outgoing (4)

Target	Relation	Type	Str
Alzheimer'S Disease	biomarker_for	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.90
transcriptomic stress	causes	phenotype	0.90
Excitatory Synapse Loss	causes	phenotype	0.85

Incoming (15)

Source	Relation	Type	Str
Apoe4	promotes	protein	0.95
Alzheimer's Disease	associated_with	disease	0.95
Digestive Exophagy	mediates	mechanism	0.90
APP MUTATION	causes	gene	0.90
ApoE4	associated_with	protein	0.90
BIN1	associated_with	gene	0.88
border-associated macrophages	associated_with	cell_type	0.85
APOE ε4 allele	associated_with	gene	0.85
APOE4	associated_with	protein	0.85
Idiopathic Normal Pressure Hydrocephalus	associated_with	disease	0.85
BIN1	involved_in	protein	0.85
Aggrecan	associated_with	protein	0.80
CGAS	expressed_in	gene	0.80
STING	expressed_in	gene	0.80
acid phosphatase	regulates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Connectotype-Vulnerability Mapping: testing whether mesoscale connectivity motif

neurodegeneration | 2026-04-25 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do connectivity motifs predict which cell types in a neurodegenerative mouse mod

closed · Rounds: 4 · Score: 0.50 · 2026-04-25

Related Research

Hypotheses and analyses mentioning AMYLOID-BETA PLAQUES in their description or question text

No additional research found