Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about anti-inflammatory: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Gallic Acid | mediates | compound | 0.90 |
| BDNF | involved_in | protein | 0.80 |
| HO-1 | promotes | gene | 0.80 |
| Kadsura coccinea | associated_with | drug | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway | 0.772 | neurodegeneration | Which specific factors in conditioned me |
| Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A | 0.669 | neurodegeneration | What are the mechanisms by which gut mic |
| Anti-inflammatory microglial reprogramming via cystatin-C/TR | 0.640 | neurodegeneration | Does the cancer-cystatin-C-TREM2 pathway |
| APOE4 dual function: beneficial astrocyte anti-inflammatory | 0.575 | alzheimers | How does APOE4's beneficial immune funct |
| LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroi | 0.498 | neuropharmacology | What is the actual quantitative contribu |
| A lower-dose 50-100 mg/day glial anti-inflammatory effect ma | 0.480 | neurodegeneration | - |
| Astrocyte Subtype-Specific Anti-Inflammatory Reprogramming | 0.000 | - | Cell type vulnerability in Alzheimers Di |
| Combinatorial TFEB Activation and Anti-Inflammatory Therapy | 0.000 | - | GBA-Synuclein Loop: Therapeutic Strategi |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Electroacupuncture ST37 treatment for DSS-induced colitis in mice | validation | colitis | 0.950 | 0.00 | mice | proposed | N/A |
| HFD-induced cognitive dysfunction and neuroinflammation in mice | validation | diet-induced cognitive dysfunc | 0.900 | 0.00 | adult Swiss male mice | proposed | N/A |
| α7nAChR agonist treatment rescues HFD-induced memory deficits | validation | diet-induced cognitive dysfunc | 0.850 | 0.00 | HFD-fed adult Swiss male mice | proposed | N/A |
| α7nAChR knockout mice show enhanced HFD sensitivity | validation | diet-induced cognitive dysfunc | 0.800 | 0.00 | Chrna7 knockout mice | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] | Teng T, Yang S, Li J, Wang H, Wu F, He Y | Neurobiology of disease | 2026 | 0 |
| Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] | Saihati HAA, Ahmed BY, Mosaad RM, El-Gar | Molecular nutrition & food res | 2026 | 0 |
| The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273] | Heiss CN, Naylor AS, Pesämaa I, Meshi A, | Front Aging Neurosci | 2026 | 0 |
| Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] | Gholizadeh F, Hajiaghayi M, Rahbari N, C | Eur J Immunol | 2026 | 0 |
| Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] | Nguyen DT, Mendoza K, Hall C, Tan C, Cha | Experimental neurology | 2026 | 0 |
| Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] | Mobasher M, Hone AJ, Pilzecker M, Bozic | Frontiers in immunology | 2026 | 0 |
| Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] | Costa SO, Silva IM, Chaves WF, Esteves A | The Journal of nutritional bio | 2026 | 0 |
| Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] | Cho Y, Kim HG, Kang JH, Oh ET, Park HJ | International journal of biolo | 2026 | 0 |
| Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703] | Feng X, Jia M, Cai M, Zhu T, Hashimoto K | Molecular psychiatry | 2025 | 0 |
| The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292] | Wolf PMK, Hanke D, Singh VK, Keller HL, | Frontiers in immunology | 2025 | 0 |
| Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] | Xia XM, Duan Y, Wang YP, Han RX, Dong YF | Acta Pharmacol Sin | 2024 | 0 |
| Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290] | ["Yang Y", "Eguchi A", "Mori C", "Hashim | Journal of affective disorders | 2024 | 0 |
| Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] | Xia XM, Duan Y, Wang YP, Han RX, Dong YF | Acta pharmacologica Sinica | 2024 | 0 |
| CD44 connects autophagy decline and ageing in the vascular endothelium. [PMID:37684253] | Unknown | Nat Commun | 2023 | 0 |
| A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depressi [PMID:36191806] | ["Yang Y", "Eguchi A", "Wan X", "Chang L | Progress in neuro-psychopharma | 2023 | 0 |
| The membrane receptor CD44: novel insights into metabolism. [PMID:35249813] | Unknown | Trends Endocrinol Metab | 2022 | 0 |
| Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to [PMID:36077246] | Newell-Rogers MK, Duong A, Nazarali R, T | International journal of molec | 2022 | 0 |
| CD44: A Multifunctional Mediator of Cancer Progression. [PMID:34944493] | Unknown | Biomolecules | 2021 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Vagus Nerve Stimulation and the Cardiovascular System. [PMID:31109966] | Capilupi MJ, Kerath SM, Becker LB | Cold Spring Harbor perspective | 2020 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning anti-inflammatory in their description or question text
Score: 0.000 · unknown disease · 2026-04-28
Reprogramming neurotoxic A1-like astrocytes to neuroprotective A2-like phenotypes through selective C3 inhibition combin
Score: 0.000 · unknown disease · 2026-04-28
Simultaneous activation of TFEB-mediated autophagy and targeted anti-inflammatory therapy would synergistically break bo