protein

HO-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HO-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

885Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HO-1 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 523 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HO
Chromosome	5q33.1
Protein Family	Heme oxygenase family
Function	Heme Oxygenase-1 (HO-1), also known as heme oxygenase (decycling) 1 (HMOX1), is a 32 kDa inducible enzyme that catalyzes the rate-limiting step in heme degradation
Subcellular Localization	Endoplasmic reticulum (membrane)
Molecular Weight	32,800 Da
Amino Acids	288 aa
Pathways	Apoptosis, Autophagy, Ferroptosis, Immune Response, Mitochondrial Function
UniProt ID	[P09601](https://www.uniprot.org/uniprot/P09601)
GeneCards	HO
Human Protein Atlas	HO
Associated Diseases	ALS, Aging, Cardiomyopathy, Inflammation, Lymphoma
Interactions	NRF2, SLC7A11, VDR, KEAP1, NLRP3, HMGB1
KG Connections	885 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HO_1["HO-1"] -->|"Produces"| bilirubin["bilirubin"]
    HO_1["HO-1"] -->|"Inhibits"| inflammation["inflammation"]
    HO_1["HO-1"] -->|"Therapeutic Target"| Fibrosis["Fibrosis"]
    HO_1["HO-1"] -->|"Therapeutic Target"| Carcinoma["Carcinoma"]
    HO_1["HO-1"] -->|"Therapeutic Target"| Als["Als"]
    HO_1["HO-1"] -->|"Therapeutic Target"| Autoimmune["Autoimmune"]
    HO_1["HO-1"] -->|"Therapeutic Target"| Ms["Ms"]
    HO_1["HO-1"] -->|"Inhibits"| Diabetes["Diabetes"]
    NRF2["NRF2"] -->|"Regulates"| HO_1["HO-1"]
    Nrf2["Nrf2"] -->|"Activates"| HO_1["HO-1"]
    ACSL4["ACSL4"] -->|"Therapeutic Target"| HO_1["HO-1"]
    GPX4["GPX4"] -->|"Therapeutic Target"| HO_1["HO-1"]
    SLC7A11["SLC7A11"] -->|"Therapeutic Target"| HO_1["HO-1"]
    style HO_1 fill:#0d47a1,color:#e0e0e0
    style bilirubin fill:#607D8B,color:#e0e0e0
    style inflammation fill:#607D8B,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Autoimmune fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Diabetes fill:#b71c1c,color:#e0e0e0
    style NRF2 fill:#0d47a1,color:#e0e0e0
    style Nrf2 fill:#0d47a1,color:#e0e0e0
    style ACSL4 fill:#8d4900,color:#e0e0e0
    style GPX4 fill:#8d4900,color:#e0e0e0
    style SLC7A11 fill:#8d4900,color:#e0e0e0

Outgoing (528)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Oxidative Stress	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Als	activates	disease	1.00
NRF2	activates	gene	1.00
NRF2	inhibits	gene	1.00
Als	inhibits	disease	1.00
NRF2	regulates	gene	1.00
BCL-2	activates	gene	1.00
Inflammation	inhibits	disease	0.95
Neurodegeneration	activates	disease	0.95
Neuroinflammation	activates	disease	0.95
bilirubin	produces	phenotype	0.90
Oxidative Stress	suppresses	process	0.90
Oxidative Stress	associated_with	pathway	0.90
Autophagy	activates	pathway	0.90
Inflammation	regulates	disease	0.85
Lymphoma	activates	disease	0.85
oxidative stress	prevents	process	0.85
oxidative stress	suppresses	process	0.85
inflammation	inhibits	phenotype	0.80
ANTIOXIDANT	promotes	process	0.80
anti-inflammatory	promotes	process	0.80
Ferroptosis	activates	pathway	0.80
Apoptosis	associated_with	pathway	0.80
Apoptosis	regulates	pathway	0.80
Oxidative Stress	inhibits	pathway	0.80
JUN	activates	gene	0.80
Ferroptosis	regulates	pathway	0.80
NEUROINFLAMMATION	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
Cancer	regulates	disease	0.75
Als	associated_with	disease	0.75
Senescence	associated_with	disease	0.75
Parkinson	activates	disease	0.75
Tumor	activates	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Stroke	inhibits	disease	0.75
Heart Failure	activates	disease	0.75
Neuroinflammation	inhibits	disease	0.75
Alzheimer	activates	disease	0.75
Nephropathy	activates	disease	0.75
Als	treats	disease	0.75
Vascular cognitive impairment	protects_against	disease	0.75
Nf-Κb	therapeutic_target	pathway	0.70
Mtor	activates	pathway	0.70
Nf-Κb	activates	pathway	0.70
NRF2	associated_with	gene	0.70
VDR	activates	gene	0.70

Incoming (357)

Source	Relation	Type	Str
OXIDATIVE STRESS	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
NRF2	regulates	protein	0.90
NRF2	activates	protein	0.90
FERROPTOSIS	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
ROS	activates	gene	0.90
Nrf2	activates	protein	0.80
NRF2	upregulates	protein	0.80
icariin	upregulates	drug	0.80
BAX	activates	gene	0.80
CAT	activates	gene	0.80
PI3K	activates	gene	0.80
NQO1	activates	gene	0.80
APOPTOSIS	associated_with	gene	0.80
OXIDATIVE STRESS	associated_with	gene	0.80
CYTOKINES	activates	gene	0.80
FERROPTOSIS	regulates	gene	0.80
TAU	activates	gene	0.80
KEAP1	activates	gene	0.80
APOPTOSIS	regulates	gene	0.80
NEUROTOXICITY	activates	gene	0.80
BCL2	associated_with	gene	0.70
BAX	associated_with	gene	0.70
GPX4	activates	gene	0.70
AMPK	activates	gene	0.70
TNF	expressed_in	gene	0.70
APOPTOSIS	inhibits	gene	0.70
KEAP1	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
CANCER	regulates	gene	0.70
NEURODEGENERATIVE DISORDERS	activates	gene	0.70
BCL2	activates	gene	0.70
GPX4	regulates	gene	0.70
SLC7A11	regulates	gene	0.70
PYROPTOSIS	regulates	gene	0.70
ROS	inhibits	gene	0.70
NEURODEGENERATIVE DISEASES	activates	gene	0.70
INFLAMMATION	inhibits	gene	0.70
FERROPTOSIS	treats	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
p-Hydroxybenzaldehyde	upregulates	compound	0.70
ACSL4	therapeutic_target	gene	0.60
GPX4	therapeutic_target	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
NRF2	associated_with	gene	0.60
GPX4	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HO-1

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

NRF2 Oxidative Stress Pathway

oxidative-stress-comparison

Sulforaphane and Nrf2 Activation for Neuroprotection

dimethyl-fumarate-nrf2-ad-nct06850597

NACET (N-Acetylcysteine Ethyl Ester)

Curcumin for Neurodegeneration

Genistein for Mild Cognitive Impairment (NCT07385937)

FOXO1 Protein

NF-kB Signaling Pathway in Neurodegeneration

alpha-lipoic-acid-neurodegeneration

Cerebral Ischemia Pathway in Neurodegeneration

FOXO4 — Forkhead Box O4

Oxidative Stress Response in 4R-Tauopathies

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease