Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HCRT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | HCRT1 |
| Full Name | HCRTR1 |
| Protein Type | Gene |
| Function | The HCRT1 (Hypocretin/Orexin 1) gene encodes the orexin-A neuropeptide, a critical regulator of arousal, wakefulness, and energy homeostasis |
| Amino Acids | 33 aa |
| Pathways | Sleep-Wake Regulation |
| GeneCards | HCRT1 |
| Human Protein Atlas | HCRT1 |
| Associated Diseases | ALS, Narcolepsy, Sleep Disorder |
| Interactions | OXR1 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HCRT1["HCRT1"]
HCRT1 -->|"expressed in"| Neuron["Neuron"]
HCRT1 -->|"activates"| HCRT["HCRT"]
HCRT1 ---|"associated"| ALS["ALS"]
HCRT1 ---|"associated"| Sleep_Disorder["Sleep Disorder"]
HCRT1 ---|"associated"| Als["Als"]
HCRT1 ---|"associated"| App["App"]
narcolepsy["narcolepsy"] -->|"activates"| HCRT1
OXR1["OXR1"] -->|"inhibits"| HCRT1
AND["AND"] ---|"associated"| HCRT1
HCRTR2["HCRTR2"] ---|"associated"| HCRT1
HCRTR1["HCRTR1"] ---|"associated"| HCRT1| Target | Relation | Type | Str |
|---|---|---|---|
| Narcolepsy | causes | disease | 0.90 |
| Sleep-Wake Regulation | involved_in | process | 0.85 |
| ALS | associated_with | disease | 0.65 |
| Sleep Disorder | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Neuron | associated_with | cell_type | 0.60 |
| App | associated_with | protein | 0.60 |
| HCRTR1 | associated_with | gene | 0.60 |
| HCRTR2 | associated_with | gene | 0.60 |
| HCRT2 | associated_with | gene | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| HCRT | associated_with | concept | 0.50 |
| CEREBROSPINAL FLUID | associated_with | concept | 0.50 |
| HCRT | activates | concept | 0.50 |
| HCRT | inhibits | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||