protein

OXR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
0Hypotheses
0Analyses
29Outgoing
1Incoming

Summary

Comprehensive protein profile: OXR1 (Oxidoreductase NRD1), a critical neuroprotective protein involved in oxidative stress resistance, mitochondrial function, and neurodegeneration

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🔬 Protein Info
Gene SymbolOXR1
Full NameOxidoreductase NRD1
AliasesSC02, C20orf70, bA204B4.3
Chromosome8q23.3
Protein TypeOxidoreductase
FunctionOXR1 is a conserved protein with oxidoreductase activity.
Primary Expressiondopaminergic neurons and is critical for their survival - oxidative stress: PD brains show increased oxidative markers; OXR1 deficiency exacerbat
Molecular Weight73 kDa
Amino Acids660 aa
Exons17
PathwaysOxidative Stress
UniProt IDQ9C0A1
NCBI Gene ID55074
GeneCardsOXR1
Human Protein AtlasOXR1
Associated Diseasesneurodegeneration
InteractionsSTAT3, NRF2, HCRT, AND, NEURODEGENERATION, DMSO
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: OXR1 — AlphaFold Q9C0A1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

OXR1 — Oxidoreductase NRD1

gene · 585 words

OXR1 Protein (Oxidoreductase NRD1)

protein · 1339 words

Supraoptic Nucleus Oxytocin Neurons

cell · 1163 words

Hypothalamic Orexin Neurons

cell · 1065 words

Nucleus Incertus (NI)

cell · 773 words

Orexin Receptor Neurons

cell · 582 words

Pathway Diagram

graph TD
    OXR1("OXR1")
    Inflammation{"Inflammation"}
    OXR1 -->|"therapeutic_target"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    OXR1 -->|"therapeutic_target"| Neuroinflammation
    Ms{"Ms"}
    OXR1 -->|"therapeutic_target"| Ms
    Alzheimer{"Alzheimer"}
    OXR1 -->|"therapeutic_target"| Alzheimer
    IL6["IL6"]
    OXR1 -->|"therapeutic_target"| IL6
    AMYLOID["AMYLOID"]
    OXR1 -->|"therapeutic_target"| AMYLOID
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    OXR1 -->|"therapeutic_target"| NEUROINFLAMMATION
    ALZHEIMER["ALZHEIMER"]
    OXR1 -->|"therapeutic_target"| ALZHEIMER
    AND["AND"]
    OXR1 -->|"activates"| AND
    MICROGLIA["MICROGLIA"]
    OXR1 -->|"therapeutic_target"| MICROGLIA
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    OXR1 -->|"therapeutic_target"| ALZHEIMER_S_DISEASE
    STAT3["STAT3"]
    OXR1 -->|"activates"| STAT3
    APP["APP"]
    OXR1 -->|"therapeutic_target"| APP
    APP_PS1["APP/PS1"]
    OXR1 -->|"therapeutic_target"| APP_PS1
    NRF2["NRF2"]
    OXR1 -->|"activates"| NRF2

Outgoing (29)

TargetRelationTypeStr
Inflammationtherapeutic_targetdisease0.65
Neuroinflammationtherapeutic_targetdisease0.65
Mstherapeutic_targetdisease0.65
Alzheimertherapeutic_targetdisease0.65
Neurodegenerationinhibitsdisease0.65

Incoming (1)

SourceRelationTypeStr
OXIDATIVE STRESSactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found