Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OXR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive protein profile: OXR1 (Oxidoreductase NRD1), a critical neuroprotective protein involved in oxidative stress resistance, mitochondrial function, and neurodegeneration
| Gene Symbol | OXR1 |
| Full Name | Oxidoreductase NRD1 |
| Aliases | SC02, C20orf70, bA204B4.3 |
| Chromosome | 8q23.3 |
| Protein Type | Oxidoreductase |
| Function | OXR1 is a conserved protein with oxidoreductase activity. |
| Primary Expression | dopaminergic neurons and is critical for their survival - oxidative stress: PD brains show increased oxidative markers; OXR1 deficiency exacerbat |
| Molecular Weight | 73 kDa |
| Amino Acids | 660 aa |
| Exons | 17 |
| Pathways | Oxidative Stress |
| UniProt ID | Q9C0A1 |
| NCBI Gene ID | 55074 |
| GeneCards | OXR1 |
| Human Protein Atlas | OXR1 |
| Associated Diseases | neurodegeneration |
| Interactions | STAT3, NRF2, HCRT, AND, NEURODEGENERATION, DMSO |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
OXR1("OXR1")
Inflammation{"Inflammation"}
OXR1 -->|"therapeutic_target"| Inflammation
Neuroinflammation{"Neuroinflammation"}
OXR1 -->|"therapeutic_target"| Neuroinflammation
Ms{"Ms"}
OXR1 -->|"therapeutic_target"| Ms
Alzheimer{"Alzheimer"}
OXR1 -->|"therapeutic_target"| Alzheimer
IL6["IL6"]
OXR1 -->|"therapeutic_target"| IL6
AMYLOID["AMYLOID"]
OXR1 -->|"therapeutic_target"| AMYLOID
NEUROINFLAMMATION["NEUROINFLAMMATION"]
OXR1 -->|"therapeutic_target"| NEUROINFLAMMATION
ALZHEIMER["ALZHEIMER"]
OXR1 -->|"therapeutic_target"| ALZHEIMER
AND["AND"]
OXR1 -->|"activates"| AND
MICROGLIA["MICROGLIA"]
OXR1 -->|"therapeutic_target"| MICROGLIA
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
OXR1 -->|"therapeutic_target"| ALZHEIMER_S_DISEASE
STAT3["STAT3"]
OXR1 -->|"activates"| STAT3
APP["APP"]
OXR1 -->|"therapeutic_target"| APP
APP_PS1["APP/PS1"]
OXR1 -->|"therapeutic_target"| APP_PS1
NRF2["NRF2"]
OXR1 -->|"activates"| NRF2| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | therapeutic_target | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| IL6 | therapeutic_target | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| APP | therapeutic_target | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| HCRT | inhibits | gene | 0.60 |
| AMYLOID | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| AND | activates | gene | 0.60 |
| MICROGLIA | therapeutic_target | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| APP/PS1 | therapeutic_target | gene | 0.60 |
| Amyloid | therapeutic_target | pathway | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| NEURODEGENERATION | inhibits | gene | 0.60 |
| DMSO | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| HCRT | associated_with | concept | 0.50 |
| HCRT | expressed_in | concept | 0.50 |
| HCRT1 | associated_with | gene | 0.50 |
| CEREBROSPINAL FLUID | associated_with | concept | 0.50 |
| HCRT1 | inhibits | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OXIDATIVE STRESS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||