Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about narcolepsy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | HCRT, HCRTR1, HCRTR2 |
| KG Connections | 35 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
narcolepsy["<b>narcolepsy</b>"]
HCRT["HCRT"]
HCRT -->|"causes"| narcolepsy
HCRTR1["HCRTR1"]
HCRTR1 -->|"associated with"| narcolepsy
HCRTR2["HCRTR2"]
HCRTR2 -->|"associated with"| narcolepsy
NEURONS["NEURONS"]
narcolepsy -->|"associated with"| NEURONS
EPIGENETIC["EPIGENETIC"]
narcolepsy -->|"associated with"| EPIGENETIC
Autoimmune["Autoimmune"]
narcolepsy -->|"causes"| Autoimmune
NEURONS["NEURONS"]
narcolepsy -->|"causes"| NEURONS
HCRT["HCRT"]
narcolepsy -->|"causes"| HCRT
HCRT["HCRT"]
narcolepsy -->|"associated with"| HCRT
Autoimmune["Autoimmune"]
narcolepsy -->|"associated with"| Autoimmune
ALZHEIMER["ALZHEIMER"]
narcolepsy -->|"associated with"| ALZHEIMER
Alzheimer_S_Disease["Alzheimer'S Disease"]
narcolepsy -->|"associated with"| Alzheimer_S_Disease
disease["disease"]
narcolepsy -->|"associated with"| disease
ALZHEIMER_S["ALZHEIMER'S"]
narcolepsy -->|"associated with"| ALZHEIMER_S
Neurodegeneration["Neurodegeneration"]
narcolepsy -->|"causes"| Neurodegeneration
disease["disease"]
narcolepsy -->|"causes"| disease
HCRT1["HCRT1"]
narcolepsy -->|"activates"| HCRT1
HCRT["HCRT"]
narcolepsy -->|"activates"| HCRT
ATAXIN_3["ATAXIN-3"]
narcolepsy -->|"associated with"| ATAXIN_3
PARKINSON["PARKINSON"]
narcolepsy -->|"associated with"| PARKINSON
Parkinson_s_Disease["Parkinson's Disease"]
narcolepsy -->|"associated with"| Parkinson_s_Disease
PARKINSON_S["PARKINSON'S"]
narcolepsy -->|"associated with"| PARKINSON_S
NEURONS["NEURONS"]
narcolepsy -->|"activates"| NEURONS
Neurodegeneration["Neurodegeneration"]
narcolepsy -->|"interacts with"| Neurodegeneration
NEURONS["NEURONS"]
narcolepsy -->|"interacts with"| NEURONS
HYPOTHALAMUS["HYPOTHALAMUS"]
narcolepsy -->|"interacts with"| HYPOTHALAMUS
Sleep_Wake["Sleep-Wake"]
narcolepsy -->|"associated with"| Sleep_Wake
Genes["Genes"]
narcolepsy -->|"associated with"| Genes
CEREBROSPINAL_FLUID["CEREBROSPINAL FLUID"]
narcolepsy -->|"associated with"| CEREBROSPINAL_FLUID
HCRTR2["HCRTR2"]
narcolepsy -->|"expressed in"| HCRTR2| Target | Relation | Type | Str |
|---|---|---|---|
| HCRT | causes | concept | 0.50 |
| HCRT | associated_with | concept | 0.50 |
| HCRT | activates | concept | 0.50 |
| HCRTR2 | expressed_in | gene | 0.50 |
| HCRTR1 | expressed_in | gene | 0.50 |
| HCRTR2 | regulates | gene | 0.50 |
| HCRTR1 | regulates | gene | 0.50 |
| HCRTR2 | inhibits | gene | 0.50 |
| HCRTR1 | inhibits | gene | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| Autoimmune | causes | disease | 0.50 |
| NEURONS | causes | concept | 0.50 |
| Autoimmune | associated_with | disease | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| Neurodegeneration | causes | disease | 0.50 |
| disease | causes | disease | 0.50 |
| HCRT1 | activates | gene | 0.50 |
| ATAXIN-3 | associated_with | protein | 0.50 |
| PARKINSON | associated_with | gene | 0.50 |
| Parkinson's Disease | associated_with | disease | 0.50 |
| PARKINSON'S | associated_with | concept | 0.50 |
| NEURONS | activates | concept | 0.50 |
| Neurodegeneration | interacts_with | disease | 0.50 |
| NEURONS | interacts_with | concept | 0.50 |
| HYPOTHALAMUS | interacts_with | concept | 0.50 |
| CEREBROSPINAL FLUID | associated_with | concept | 0.50 |
| ATAXIN-3 | regulates | protein | 0.50 |
| Cortex | regulates | brain_region | 0.50 |
| FRONTAL | regulates | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||